Structure of Vitamin E Polyethylene Glycol Succinate(TPGS) CAS 9002-96-4

Vitamin E Polyethylene Glycol Succinate(TPGS) CAS 9002-96-4

Identification

CAS Number

9002-96-4

Name

Vitamin E Polyethylene Glycol Succinate(TPGS)

Synonyms

2-Hydroxyethyl 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-chromen-6-yl succinate [ACD/IUPAC Name]
2-Hydroxyethyl-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-chromen-6-yl-succinat [German] [ACD/IUPAC Name]
Butanedioic acid, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl 2-hydroxyethyl ester [ACD/Index Name]
Succinate de 2-hydroxyéthyle et de 2,5,7,8-tétraméthyl-2-(4,8,12-triméthyltridécyl)-3,4-dihydro-2H-chromén-6-yle [French] [ACD/IUPAC Name]
(+)-α-Tocopheryl polyethylene glycol 1000 succinate
1-O-(2-hydroxyethyl) 4-O-[2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-yl] butanedioate
30999-06-5 [RN]
32408-94-9 [RN]
58829-13-3 [RN]
9002-96-4 [RN]
Aquasol E Tpgs Liquid 77iu/Ml
D 1T
D-α-Tocopheryl poly(ethylene glycol) 1000 succinate
D-α-Tocopheryl poly(ethylene glycol)1000 succinate
MFCD00146616
Tocofersolan
Tocofersolan (inn)
Tocofersolan [inn]
Tocofersolan, INN
Tocofersolano [Spanish]
Tocofersolano
Tocofersolanum [Latin]
Tocofersolanum
Tocophersolan
Tocophersolan (usan)
Tocophersolan [usan] [USAN]
Tocophersolan, USAN
TPGS
vitamin E-TPGS

SMILES

Cc1c(c(c(c2c1OC(CC2)(C)CCCC(C)CCCC(C)CCCC(C)C)C)OC(=O)CCC(=O)OCCO)C

StdInChI

InChI=1S/C35H58O6/c1-24(2)12-9-13-25(3)14-10-15-26(4)16-11-20-35(8)21-19-30-29(7)33(27(5)28(6)34(30)41-35)40-32(38)18-17-31(37)39-23-22-36/h24-26,36H,9-23H2,1-8H3

StdInChIKey

AOBORMOPSGHCAX-UHFFFAOYSA-N

Molecular Formula

C33H54O5.(C2H4O)n

MDL Number

MFCD00146616

Properties

Appearance

Off-white or yellowish waxy solid

Melting Point

36 °C

Safety Data

Personal Protective Equipment

Eyeshields, Gloves, type N95 (US)

RIDADR 

NONH for all modes of transport

WGK Germany

2

Specifications and Other Information of Our Vitamin E Polyethylene Glycol Succinate(TPGS) CAS 9002-96-4

Identification Methods

HPLC

D-α-tocopherol Assay

≥26.0%

mono-TPGS

≥80.0%

bis-TPGS

≤10.0%

Vitamin E

≤1.5%

Vitamin E Succinate

≤0.2%

Solubility in water

20% Min (Clear solution within 3h)

Acidity

≤0.27mL

Specific Rotation

≥+24.0°

Heavy metals

≤10ppm

Residual solvents

Ethyl acetate

≤50ppm

Ethanol

≤50ppm

Methyl ethyl ketone

≤10ppm

Shelf Life

2 years

Storage

Store in tightly closed containers at room temperature. Protected from moisture and pest infestation.

Productivity

5MT/month

Description

D -α-tocopheryl polyethylene glycol 1000 succinate is a water-soluble
derivative of natural-source vitamin E. Off-white or yellowish waxy solid, almost tasteless, soluble in water and most of the polar organic solvents such as ethanol. It is amphipathic, miscible with water, and forms a variety of liquid crystalline phases in water. The excipient melts at 37–41℃ and is heat stable at temperatures ≤200℃.

Known Application

1) As a solubilizer:
TPGS increases the permeability of amprenavir by inhibiting efflux. Amprenavir is a new HIV protease inhibitor. At present, Amprenavir products which use TPGS as an excipient are currently available in the United States, such as Agenerase ™ oral liquid and capsules. It has also been reported that micellar solubilization of TPGS increases estradiol solubility and transdermal permeation. After combined with cyclosporine A, TPGS increased the solubility of cyclosporine A, thereby enhancing the cyclosporine A bioavailability.
2) Apply to solid dispersion technology:
Water-soluble excipient such as lactose, mannitol, hydroxypropyl methyl cellulose and the like are added into the TPGS drug mixture to accelerate drug release. Adding hydrophobic materials, such as wax, can slow down dissolution. In addition, an expansiveness excipient can be added at the bottom of the capsule, and then expanded after exposure to water thus pushing the liquid crystal matrix into the intestinal tract.
3) As a plasticizer:
TPGS as a plasticizer reduce the interaction among the polymer molecules, so that the polymer chains are more likely to move. It provides polymer molecules with greater freedom mobile space, allowing more stretching and elastic membrane.
4) As an emulgator:
TPGS is amphiphilic. Experiments show that both in water and oil phase, TPGS has such high entrapment efficiency.
5) As a sorbefacient:
TPGS can improve gastrointestinal absorption of animals and people.
6) Others:
TPGS is waxy solid at room temperature. As an ophthalmic preparation, the viscosity is high which can extend the residence time on the surface of the cornea, reduce the stimulus and significantly increase the solubility of indissolvable drug in the eye. As a surfactant, it can make sprays from Glucocorticoid Beclometasone Dipropionate and treat respiratory illness through nasal drug delivery.

Process Flow sheet

Process Flow sheet
Process Flow sheet

Caming Pharmaceutical Ltd

This product is developed by our sub R&D company Caming Pharmaceutical Ltd, and please click the link below for details. http://www.caming.com/vitamin-e-polyethylene-glycol-succinatetpgs-cas-9002-96-4/

Watson International Ltd

This product is sold exclusively through our sales company Watson International Ltd, and please click the link below for details. http://www.watson-int.com/vitamin-e-polyethylene-glycol-succinatetpgs-cas-9002-96-4/