Structure of Tetracosactide Acetate CAS 16960-16-0

Tetracosactide Acetate CAS 16960-16-0

Identification
Properties
Safety Data
Specifications & Other Information
Links

Identification

CAS Number

16960-16-0

Name

Tetracosactide Acetate

Sequence

Ser-Tyr-Ser-Met-Glu-His-Phe- Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys- Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr- Pro

Synonyms

16960-16-0 [RN]
Cortrosyn [Trade name]
cosyntropin [USAN]
L-Proline, L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-v
alyl-L-lysyl-L-valyl-L-tyrosyl- [ACD/Index Name]
L-proline, L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysyl-L-valyl-L-tyrosyl-
L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysy
L-Seryl-L-tyrosyl-L-seryl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysy
l-L-valyl-L-tyrosyl-L-prolin [German] [ACD/IUPAC Name]
L-Seryl-L-tyrosyl-L-seryl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysy
l-L-valyl-L-tyrosyl-L-proline [ACD/IUPAC Name]
L-Séryl-L-tyrosyl-L-séryl-L-méthionyl-L-α-glutamyl-L-histidyl-L-phénylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysy
l-L-valyl-L-tyrosyl-L-proline [French] [ACD/IUPAC Name]
L-Seryl-L-tyrosyl-L-seryl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysyl-L-valyl-L-tyrosyl-L-proline
Porcine ACTH (1-24)
tetracosactida [Spanish] [INN]
Tetracosactide [INN] [Wiki]
tétracosactide [French] [INN]
tetracosactidum [Latin] [INN]
y-29-(4-hydroxybenzyl)-26-(hydroxymethyl)-17-(1H-imidazol-4-ylmethyl)-8-(1H-indol-3-ylmethyl)-23-[2-(methylsulfanyl)ethyl]-4,7,10,13,16,19,22,25,28,31-decaoxo-3,6,9,12,15,18,21,24,27,30-decaazatritria
α1-24-Corticotropin
тетракозактид [Russian] [INN]
تيتراكوساكتيد [Arabic] [INN]
替可克肽 [Chinese] [INN]
??1-24-corticotrophin
[16960-16-0]
a1-24-Corticotropin
ACTH (1-24) (human, bovine, rat)
ACTH (1-24), Human
ACTH(1-24)
Actholain
Adrenocorticotropic hormone 1-24
Adrenocorticotropic hormone fragment 1-24 human, rat
ATCH (1-24)
Corticotropin tetracosapeptide
Corticotropin-(1-24)
corticotropin-(1-24) tetracosapeptide
Cortrophin S
L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysyl-L-valyl-L-tyrosyl-L-prolyline
MFCD00167476 [MDL number]
SerTyrSerMetGluHisPheArgTrpGlyLysProValGlyLysLysArgArgProValLysValTyrPro
Synacthene-retard
SYSMEHFRWGKPVGKKRRPVKVYP
Tetracosactid
tetracosactrin
Tetracosapeptide
α(1-24)-corticotrophin
β(1-24)-corticotrophin

Molecular Structure

Structure of Tetracosactide Acetate CAS 16960-16-0

Structure of Tetracosactide Acetate CAS 16960-16-0

SMILES

CC(C)[C@@H](C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N3CCC[C@H]3C(=O)O)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC7=CC=CC=C7)NC(=O)[C@H](CC8=CN=CN8)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)[C@H](CC9=CC=C(C=C9)O)NC(=O)[C@H](CO)N

StdInChI

InChI=1S/C136H210N40O31S/c1-75(2)109(127(200)154-71-106(181)156-88(31-13-17-52-137)114(187)158-89(32-14-18-53-138)115(188)159-91(35-21-56-149-134(142)143)116(189)164-96(37-23-58-151-136(146)147)131(204)175-60-25-39-104(175)126(199)173-111(77(5)6)128(201)163-90(33-15-19-54-139)120(193)171-110(76(3)4)129(202)169-101(65-80-43-47-84(180)48-44-80)132(205)176-61-26-40-105(176)133(206)207)172-125(198)103-38-24-59-174(103)130(203)95(34-16-20-55-140)157-107(182)70-153-113(186)99(66-81-68-152-87-30-12-11-29-85(81)87)167-117(190)92(36-22-57-150-135(144)145)160-121(194)98(63-78-27-9-8-10-28-78)166-123(196)100(67-82-69-148-74-155-82)168-118(191)93(49-50-108(183)184)161-119(192)94(51-62-208-7)162-124(197)102(73-178)170-122(195)97(165-112(185)86(141)72-177)64-79-41-45-83(179)46-42-79/h8-12,27-30,41-48,68-69,74-77,86,88-105,109-111,152,177-180H,13-26,31-40,49-67,70-73,137-141H2,1-7H3,(H,148,155)(H,153,186)(H,154,200)(H,156,181)(H,157,182)(H,158,187)(H,159,188)(H,160,194)(H,161,192)(H,162,197)(H,163,201)(H,164,189)(H,165,185)(H,166,196)(H,167,190)(H,168,191)(H,169,202)(H,170,195)(H,171,193)(H,172,198)(H,173,199)(H,183,184)(H,206,207)(H4,142,143,149)(H4,144,145,150)(H4,146,147,151)/t86-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,109-,110-,111-/m0/s1

StdInChIKey

ZOEFCCMDUURGSE-SQKVDDBVSA-N

Molecular Formula

C136H210N40O31S

Molecular Weight

2933.5

EINECS

241-031-1

MDL Number

MFCD00167476

Properties

Appearance

White or yellow, amorphours powder

Safety Data

RIDADR

NONH for all modes of transport

WGK Germany

3

Specifications and Other Information of Our Tetracosactide Acetate CAS 16960-16-0

Standard

Enterprise standard

Identification Methods

HPLC

Assay(anhydrous and acetic acid –free substance)

90～102%

Identity by Amino Acids Analysis

Lys: 3.5~4.7
His:0.9~1.1
Arg: 2.7~3.3
Ser:1.1~2.2
Glu: 0.9~1.1
Pro: 2.5~3.5
Gly: 1.8~2.2
Met: 0.9~1.1
Tyr: 1.7~2.2
Phe:0.9~1.1

Specific Optical Rotation

-99.0～-109.0°(c=1，1%HAc)

Absorbance(0.2mg/ml 0.1M HCl)

Amax 276nm 0.51~0.61

Related Substance(By HPLC)

Total Impurities(%):≤9.0%
Any Single Impurity(%):≤2.5%

Acetate Content (By HPLC)

8.0~13.0%

Water Content(Karl Fischer)

≤14.0%

Bacterial Endotoxins

≤10IU/mg

Package

According to customer requirements to packaging

Storage

Store at 2-8℃，,Sealed and away from light

Application

For the diagnosis of adrenal insufficiency; also for the treatment of rheumatism, rheumatoid arthritis, skin diseases and shock.

Links

This product is developed by our sub R&D company Apnoke Scientific Ltd, and please click the link below for details.
http://www.apnoke.com/tetracosactide-acetate-cas-16960-16-0/

This product is sold exclusively through our sales company Watson International Ltd, and please click the link below for details.
http://www.watson-int.com/tetracosactide-acetate-cas-16960-16-0/