Structure of this intermediate CAS 288383-71-1

Tandutinib intermediate CAS 288383-71-1

Identification

CAS Number

288383-71-1

Name

4-chloro-6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinazoline

Synonyms

Tandutinib intermediate
MLN518
CT53518

Molecular Structure

Structure of this intermediate CAS 288383-71-1

SMILES

Clc3ncnc2cc(OCCCN1CCCCC1)c(OC)cc23

StdInChI

InChI=1S/C17H22ClN3O2/c1-22-15-10-13-14(19-12-20-17(13)18)11-16(15)23-9-5-8-21-6-3-2-4-7-21/h10-12H,2-9H2,1H3

StdInChIKey

QMPMEXBHMIYNGL-UHFFFAOYSA-N

Molecular Formula

C17H22ClN3O2

Molecular Weight

335.83

Properties

Appearance

White or almost white crystalline powder

Refractive Index

n20/D1.583(lit.)

Boiling Point

485.69 °C at 760 mmHg

Flash Point

247.537 °C

Density

1.215 g/ml

Safety Data

Symbol

exclamation-mark-jpgGHS07

Signal Word

Warning

Hazard Statements

H315-H319-H335

Precautionary Statements

P261-P305 + P351 + P338

Personal Protective Equipment

dust mask type(N95) US, Eye Shields, Gloves

Hazard Codes (Europe)

Xi

Risk Statements (Europe)

36/37/38-52/53

Safety Statements (Europe)

26-36

Specifications and Other Information of Our Tandutinib intermediate CAS 288383-71-1

Purity

98%min(By HPLC)

Identification

HNMR, HPLC

Known Application

It is an intermediate(CAS 288383-71-1) of the Tandutinib, which is an orally active multitargeted tyrosine kinase inhibitor that is currently under evaluation for the treatment of glioblastoma and has been used in the treatment of leukemia.

Productivity

kg scale

Watson-Int Link

http://watson-int.com/Intermediate-of-tandutinib_CAS_288383-71-1.html