Sorafenib intermediate CAS 327-78-6

Structure of Sorafenib intermediate CAS 327-78-6

Identification CAS Number 327-78-6 Name 4-Chloro-3-(trifluoromethyl)phenyl isocyanate Synonyms Intermediate of Sorafenib Molecular Structure SMILES FC(F)(F)c1cc(\N=C=O)ccc1Cl StdInChI InChI=1S/C8H3ClF3NO/c9-7-2-1-5(13-4-14)3-6(7)8(10,11)12/h1-3H StdInChIKey NBJZEUQTGLSUOB-UHFFFAOYSA-N Molecular Formula C8H3ClF3NO Molecular Weight 221.56 MDL Number MFCD00013874 Properties Appearance White to off-white crystal Refractive Index 1.487 Boiling Point 86-90 °C/14 mmHg(lit.) Melting

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Tandutinib intermediate CAS 288383-71-1

Structure of this intermediate CAS 288383-71-1

Identification CAS Number 288383-71-1 Name 4-chloro-6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinazoline Synonyms Tandutinib intermediate MLN518 CT53518 Molecular Structure SMILES Clc3ncnc2cc(OCCCN1CCCCC1)c(OC)cc23 StdInChI InChI=1S/C17H22ClN3O2/c1-22-15-10-13-14(19-12-20-17(13)18)11-16(15)23-9-5-8-21-6-3-2-4-7-21/h10-12H,2-9H2,1H3 StdInChIKey QMPMEXBHMIYNGL-UHFFFAOYSA-N Molecular Formula C17H22ClN3O2 Molecular Weight 335.83 Properties Appearance White or almost white crystalline powder Refractive Index n20/D1.583(lit.) Boiling Point 485.69 °C

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Procarbazine hydrochloride CAS 366-70-1

Structure of Procarbazine hydrochloride CAS 366-70-1

Identification CAS Number 366-70-1 Name Procarbazine hydrochloride Synonyms N-(1-Methylethyl)-4-((2-methylhydrazino)methyl)benzamide hydrochloride Molecular Structure SMILES Cl.O=C(c1ccc(cc1)CNNC)NC(C)C StdInChI InChI=1S/C12H19N3O.ClH/c1-9(2)15-12(16)11-6-4-10(5-7-11)8-14-13-3;/h4-7,9,13-14H,8H2,1-3H3,(H,15,16);1H SydInChIKey DERJYEZSLHIUKF-UHFFFAOYSA-N Molecular Formula C12H20N3OCl Molecular Weight 257.76 EINECS Number 206-678-6 MDL Number MFCD00072082 Properties Appearance White to tan powder Solubility DMSO: ≥18 mg/mL Boiling

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