Structure of Sorafenib intermediate CAS 327-78-6

Sorafenib intermediate CAS 327-78-6

Identification

CAS Number

327-78-6

Name

4-Chloro-3-(trifluoromethyl)phenyl isocyanate

Synonyms

Intermediate of Sorafenib

Molecular Structure

Structure of Sorafenib intermediate CAS 327-78-6

SMILES

FC(F)(F)c1cc(\N=C=O)ccc1Cl

StdInChI

InChI=1S/C8H3ClF3NO/c9-7-2-1-5(13-4-14)3-6(7)8(10,11)12/h1-3H

StdInChIKey

NBJZEUQTGLSUOB-UHFFFAOYSA-N

Molecular Formula

C8H3ClF3NO

Molecular Weight

221.56

MDL Number

MFCD00013874

Properties

Appearance

White to off-white crystal

Refractive Index

1.487

Boiling Point

86-90 °C/14 mmHg(lit.)

Melting Point

40-42 °C(lit.)

Flash Point

99 °C

Density

1.4 g/mL

Safety Data

Symbol

exclamation-mark-jpgGHS07

Signal Word

Warning

Hazard Statements

H302-H312-H315-H319-H332-H335

Precautionary Statements

P261-P280-P305 + P351 + P338

Personal Protective Equipment

dust mask type(N95) US, Eye Shields, Gloves

Hazard Codes (Europe)

Xn

Risk Statements (Europe)

36/37/38-52/53

Safety Statements (Europe)

7-26-27-37/39

RIDADR

UN 2206 6.1/PG 3

WGK Germany

3

Specifications and Other Information of Our Sorafenib intermediate CAS 327-78-6

Purity

99%min(By HPLC)

Identification Method

HNMR, HPLC

Known Application

The intermediate of sorafenib (CAS 327-78-6), which is a drug approved for the treatment of primary kidney cancer (advanced renal cell carcinoma) and advanced primary liver cancer (hepatocellular carcinoma)

Productivity

1000kg/month

Watson-Int Link

http://watson-int.com/Intermediate-of-sorafenib_CAS_327-78-6.html