(S)-4-ETHYL-4-HYDROXY-7,8-DIHYDRO-1H-PYRANO[3,4-F]INDOLIZINE-3,6,10(4H)-TRIONE CAS 110351-94-5
Identification
Properties
Safety Data
Specifications & Other Information
Links
Identification
CAS Number
110351-94-5
Name
(S)-4-ETHYL-4-HYDROXY-7,8-DIHYDRO-1H-PYRANO[3,4-F]INDOLIZINE-3,6,10(4H)-TRIONE
Synonyms
(4S)-4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizin-3,6,10(4H)-trion [German] [ACD/IUPAC Name]
(4S)-4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione [ACD/IUPAC Name]
(4S)-4-Éthyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione [French] [ACD/IUPAC Name]
(s)-8-Ethyl-8-hydroxy-2,3,5,8-tetrahydro-6-oxa-3a-aza-cyclopenta[b]naphthalene-1,4,7-trione
1H-Pyrano[3,4-f]indolizine-3,6,10(4H)-trione, 4-ethyl-7,8-dihydro-4-hydroxy-, (4S)- [ACD/Index Name]
(4S)-4-ETHYL-4-HYDROXY-1H,3H,4H,6H,7H,8H,10H-PYRANO[3,4-F]INDOLIZINE-3,6,10-TRIONE
(4S)-4-ETHYL-4-HYDROXY-1H,7H,8H-PYRANO[3,4-F]INDOLIZINE-3,6,10-TRIONE
(4S)-4-ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10-trione
(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f
(4S)-4-Ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
(S)-4-ETHYL-4-HYDROXY-7,8-DIHYDRO-1H-PYRANO[3,4-F]INDOLIZINE-3,6,10(4H)-TRIONE
(S)-4-hydroxy-4-propyl-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3
(S)-4-hydroxy-4-propyl-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
[110351-94-5]
110351-94-5 [RN]
1H-Pyrano[3,4-f]indolizine-3,6,10(4H)-trione,4-ethyl-7,8-dihydro-4-hydroxy-, (4S)-
ANW-72103
CTK4A6861
IGKWOGMVAOYVSJ-ZDUSSCGKSA-N
MFCD09833229
MFCD17011873 [MDL number]
MolPort-005-933-313
SCHEMBL614060
ZINC01616399
Molecular Structure
![Structure of (S)-4-ETHYL-4-HYDROXY-7,8-DIHYDRO-1H-PYRANO[3,4-F]INDOLIZINE-3,6,10(4H)-TRIONE CAS 110351-94-5](https://watsonnoke.com/wp-content/uploads/2017/06/Structure-of-S-4-ETHYL-4-HYDROXY-78-DIHYDRO-1H-PYRANO34-FINDOLIZINE-36104H-TRIONE-CAS-110351-94-5.png)
SMILES
CC[C@@]1(c2cc3n(c(=O)c2COC1=O)CCC3=O)O
StdInChI
InChI=1S/C13H13NO5/c1-2-13(18)8-5-9-10(15)3-4-14(9)11(16)7(8)6-19-12(13)17/h5,18H,2-4,6H2,1H3/t13-/m0/s1
StdInChIKey
IGKWOGMVAOYVSJ-ZDUSSCGKSA-N
Molecular Formula
C13H13NO5
Molecular Weight
263.246
MDL Number
MFCD17011873
Properties
Appearance
Light yellow solid
Melting Point
185℃
Safety Data
Signal Word
Warning
WGK Germany
3
Specifications and Other Information of Our (S)-4-ETHYL-4-HYDROXY-7,8-DIHYDRO-1H-PYRANO[3,4-F]INDOLIZINE-3,6,10(4H)-TRIONE CAS 110351-94-5
Standard
Enterprise standard
Identification Methods
HNMR,HPLC
Purity
95%min
Specific Optical Rotation
+76°~+78° (c 0.62, CHCl3)
Storage
Preserved in tight containers
Application
It is the key intermediate for the synthesis of a series of (20S)-camptothecin analogues. Since its isolation from the Chinese plant Camptothecaacuminata by Wall et al. In 1966, (20S)-camptothecin, a pent acyclic natural alkaloid, has re-emerged as one of the most important lead compounds for the discovery of new and selective anticancer drugs because of the disclosure of its unique mechanism of action as a selective inhibitor DNA topoisomerase Ⅰ, a process causing irreversible DNA damage and subsequent cell death. Three camptothecin derivatives with high antitumor activity, topotecan, belotecan, and irinotecan, have been launched as anticancer drugs in clinical practice, and many other analogues are at various stages of clinical development.
General View of Documents
Links
Caming Pharmaceutical Ltd
This product is developed by our sub R&D company Caming Pharmaceutical Ltd, and please click the link below for details.
http://www.caming.com/s-4-ethyl-4-hydroxy-78-dihydro-1h-pyrano34-findolizine-36104h-trione-cas-110351-94-5/
Watson International Ltd
This product is sold exclusively through our sales company Watson International Ltd, and please click the link below for details.
http://www.watson-int.com/s-4-ethyl-4-hydroxy-78-dihydro-1h-pyrano34-findolizine-36104h-trione-cas-110351-94-5/