Rotigotine hydrochloride CAS 99755-59-6 (125572-93-2)
Identification
Name
Rotigotine hydrochloride
CAS Number
99755-59-6 (125572-93-2)
Synonyms
(−)-(S)-5,6,7,8-Tetrahydro-6-(propyl(2-(2-thienyl)ethyl)amino)-1-naphthol hydrochloride
(−)-N 0437
N 0923
Neupro
SPM 962
(6S)-6-{Propyl[2-(2-thienyl)ethyl]amino}-5,6,7,8-tetrahydronaphthalen-1-ol hydrochloride (1:1)
(6S)-6-{propyl[2-(thiophen-2-yl)ethyl]amino}-5,6,7,8-tetrahydronaphthalen-1-ol hydrochloride (1:1)
1-Naphthalenol, 5,6,7,8-tetrahydro-6-(propyl(2-(2-thienyl)ethyl)amino)-, hydrochloride, (S)-
1-Naphthalenol, 5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-, (6S)-, hydrochloride (1:1)
(-)-5,6,7,8-Tetrahydro-6-(propyl(2-(2-thienyl)ethyl)amino)-1-naphthol hydrochloride
(6S)-5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenol hydrochloride
(6S)-6-(propyl-(2-thiophen-2-ylethyl)amino)tetralin-1-ol hydrochloride
(6S)-6-[propyl(2-thiophen-2-ylethyl)amino]-5,6,7,8-tetrahydronaphthalen-1-ol hydrochloride
(S)-5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenol hydrochloride
(S)-6-(propyl(2-(thiophen-2-yl)ethyl)amino)-5,6,7,8-tetrahydronaphthalen-1-ol hydrochloride
1-naphthalenol, 5,6,7,8-tetrahydro-6-(propyl(2-(2-thienyl)ethyl)amino)-, hydrochloride,(s)-
5-HYDROXY-2-(N-PROPYL-N-2-(2-THIENYL)ETHYLAMINO)-TETRALIN HYDROCHLORIDE,L-
rotigotine HCl
Rotigotine hydrochloride
Molecular Structure
SMILES
[Cl-].Oc1cccc3c1CC[C@H]([NH+](CCC)CCc2sccc2)C3
StdInChI
InChI=1S/C19H25NOS.ClH/c1-2-11-20(12-10-17-6-4-13-22-17)16-8-9-18-15(14-16)5-3-7-19(18)21;/h3-7,13,16,21H,2,8-12,14H2,1H3;1H/t16-;/m0./s1
StdInChIKey
CEXBONHIOKGWNU-NTISSMGPSA-N
Molecular Formula
C19H25NOS.HCl
Molecular Weight
351.93
MDL Number
MFCD00906149
Properties
Appearance
White or almost white powder
Solubility
DMSO:>10 mg/mL
Safety Data
Symbol
GHS07
Signal Word
Warning
Hazard Statements
Hazard Codes (Europe)
Risk Statements (Europe)
WGK Germany
2
Specifications and Other Information of Our Rotigotine hydrochloride CAS 99755-59-6 (125572-93-2)
Purity
97.0%min(By HPLC)
Identification Method
IR, HPLC
Optical Rotation
-50°–55°
Related Substances
3.0% max
Known Application
is a dopamine agonist of the non-ergoline class of medications indicated for the treatment of Parkinson’s disease (PD) and Willis-Ekbom Disease (WED) formerly known as restless legs syndrome (RLS) in Europe and the United States.
Productivity
100kg/month
Package
5kg/bag
Storage
Stored under room temperature away from light
General View of Documents
Available Intermediates
Impurity 1: Rotigotine
CAS: 92206-54-7
Structure:
Appearance: White or almost white solid
Purity: 97.0%min
Related Substances: 3.0% max
Impurity 2: (6S)-(-)-5-Hydroxy-N-propyl-2-aminotetralin hydrobromide
CAS: 165950-84-5
Structure:
Appearance: White or almost white powder
Purity: 95.0%min
Related Substances: 5.0% max
Impurity 3: (S)-1,2,3,4-Tetrahydro-5-methoxy-N-propyl-2-naphthalenamine
CAS: 93601-86-6
Structure:
Appearance: White or almost white powder
Purity: 95%.0min
Related Substances: 5.0% max
Impurity 4: 2-(2-Thienyl)ethyl 4-methylbenzenesulfonate
CAS: 40412-06-4
Structure:
Appearance: White or almost white solid
Purity: 98.0%min
Related Substances: 2.0% max
Single Impurity: 0.5% max
Impurity 5: 5-Methoxy-2-tetralone
CAS: 32940-15-1
Structure:
Appearance: A faint yellow or white crystal
Purity: 98.0%min
Beta-Tetralone: 0.5% max
1,6-Dimethoxynaphthalene: 0.5% max
Watson-Int Link
http://watson-int.com/Rotigotine-HCL_CAS_99755-59-6_125572-93-2.html