R-alpha-Lipoic acid tromethamine salt CAS 14358-90-8
Identification
Properties
Safety Data
Specifications & Other Information
Links
Identification
CAS Number
14358-90-8
Name
R-alpha-Lipoic acid tromethamine salt
Synonyms
1,2-Dithiolane-3-pentanoic acid, compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1) [ACD/Index Name]
14358-90-8 [RN]
238-329-9 [EINECS]
5-(1,2-Dithiolan-3-yl)pentanoic acid – 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1) [ACD/IUPAC Name]
5-(1,2-Dithiolan-3-yl)pentansäure –2-amino-2-(hydroxymethyl)-1,3-propandiol (1:1) [German] [ACD/IUPAC Name]
Acide 5-(1,2-dithiolan-3-yl)pentanoïque – 2-amino-2-(hydroxyméthyl)-1,3-propanediol (1:1) [French] [ACD/IUPAC Name]
UNII:V8276EBZ06
1,2-dithiolane-3-valeric acid, compound with 2-amino-2-(hydroxymethyl)propane-1,3-diol (1:1)
2-amino-2-(hydroxymethyl)propane-1,3-diol; 5-(3-dithiolanyl)pentanoic acid
2-azanyl-2-(hydroxymethyl)propane-1,3-diol
5-(3-dithiolanyl)pentanoic acid
6,8-THIOCTIC ACID
R-α-Lipoic acid tromethamine salt
R-α-Lipoic acidtromethaminesalt
THIOCTATE TROMETAMOL
tris buffer
Molecular Structure
SMILES
C1CSSC1CCCCC(=O)O.C(C(CO)(CO)N)O
StdInChI
InChI=1S/C8H14O2S2.C4H11NO3/c9-8(10)4-2-1-3-7-5-6-11-12-7;5-4(1-6,2-7)3-8/h7H,1-6H2,(H,9,10);6-8H,1-3,5H2
StdInChIKey
CCTREOMTIFSZAU-UHFFFAOYSA-N
Molecular Formula
C12H25NO5S2
Molecular Weight
327.46
Properties
Appearance
Off-white or pale yellow crystal powder
Melting Point
115~120℃
Safety Data
WGK Germany
3
Specifications and Other Information of Our R-alpha-Lipoic acid tromethamine salt CAS 14358-90-8
Standard
Enterprise standard
Identification Methods
HNMR,HPLC
Purity
99%min
Optical purity
99%min
Specific Optical Rotation
+67°~+77°
Heavy Metals
20ppm max
Loss on Drying
0.5%max
Residue on Ignition
0.2%max
Package
According to customer requirements to packaging
Storage
Under the room temperature and away from light
Application
Lipoic acid (LA), also known as alpha lipoic acid (ALA) and thioctic acid is an organosulfur compound which is widely used as a dietary supplement in some countries marketed as an antioxidant and is available as a pharmaceutical drug in other countries.
Alpha-Lipoic Acid bulk material available today is (R/S) or (+/-) Alpha Lipoic Acid (ALA), meaning it contains a 50/50 mixture of (R-Lipoic) and unnatural (S-Lipoic) Lipoic Acid. The S-Lipoic Acid form, which is not found anywhere in nature, is a byproduct of chemical synthesis. Research indicates that not only does the human body have difficulty absorbing this unnatural version, it may inhibit the most essential properties of the R-Lipoic Acid form!
The “R” form (R Lipoic) is considered the “eutomer” (the biologically superior form) of Alpha Lipoic Acid, since it is identical to that produced by the body. Research indicates R-Lipoic Acid is responsible for most of the beneficial effects attributed to ALA.
While R Lipoic Acid is the obvious choice over Alpha Lipoic Acid, pure R-Lipoic Acid in its “free-acid” form has two major drawbacks: stability and bioavailability. Without special processing, R-Lipoic Acid is highly unstable and difficult to absorb. In fact, pharmacokinetic data reveal that while Alpha Lipoic Acid has a very low absorption rate, unstabilized R-Lipoic Acid is absorbed even worse!
As one of the largest fine chemical developers globally, Watson solved the stability issue by bringing in two other derivates R(+)-Alpha Lipoic Acid Sodium CAS 176110-81-9 and R-alpha-Lipoic acid tromethamine salt CAS 14358-90-8, being one of the world’s largest purveyor of commercially produced stabilized R-Lipoic Acid materials.
You know check here to know more about our two products,
R (+)-Alpha Lipoic Acid Sodium CAS 176110-81-9: http://www.watson-int.com/r-alpha-lipoic-acid-sodium-cas-176110-81-9/
R-(+)-alpha-Lipoic acid CAS 1200-22-2: http://www.watson-int.com/r-alpha-lipoic-acid-cas-1200-22-2/
General View of Documents
Links
Ulcho Biochemical Ltd
This product is developed by our sub R&D company Ulcho Biochemical Ltd, and please click the link below for details.
http://www.ulcho.com/r-alpha-lipoic-acid-tromethamine-salt-cas-14358-90-8/
Watson International Ltd
This product is sold exclusively through our sales company Watson International Ltd, and please click the link below for details.
http://www.watson-int.com/r-alpha-lipoic-acid-tromethamine-salt-cas-14358-90-8/
