Structure of Nimbolide CAS 25990-37-8

Nimbolide CAS 25990-37-8

Identification

CAS Number

25990-37-8

Name

Nimbolide

Synonyms

[(2aR,5aR,6S,6aR,8R,9aR,10aS,10bR,10cR)-8-(3-Furyl)-2a,5a,6a,7-tétraméthyl-2,5-dioxo-2a,5a,6,6a,8,9,9a,10a,10b,10c-décahydro-2H,5H-cyclopenta[b]furo[2′,3′,4′:4,5]naphto[2,3-d]furan-6-yl]acétate de mét hyle [French] [ACD/IUPAC Name]
25990-37-8 [RN]
2H,5H-Cyclopenta[d]naphtho[2,3-b:1,8-b’c’]difuran-6-acetic acid, 8-(3-furanyl)-2a,5a,6,6a,8,9,9a,10a,10b,10c-decahydro-2a,5a,6a,7-tetramethyl-2,5-dioxo-, methyl ester, (2aR,5aR,6S,6aR,8R,9aR,10aS,10bR ,10cR)- [ACD/Index Name]
2H,5H-cyclopenta[d]naphtho[2,3-b:1,8-b’c’]difuran-6-acetic acid, 8-(3-furanyl)-2a,5a,6,6a,8,9,9a,10a,10b,10c-decahydro-2a,5a,6a,7-tetramethyl-2,5-dioxo-, methyl ester, (2aR,5aR,6S,6aR,8R,9aR,10aS,10bR,10cR)-
GY2370000
Methyl [(2aR,5aR,6S,6aR,8R,9aR,10aS,10bR,10cR)-8-(3-furyl)-2a,5a,6a,7-tetramethyl-2,5-dioxo-2a,5a,6,6a,8,9,9a,10a,10b,10c-decahydro-2H,5H-cyclopenta[b]furo[2′,3′,4′:4,5]naphtho[2,3-d]furan-6-yl]acetat e [ACD/IUPAC Name]
Methyl [(2aR,5aR,6S,6aR,8R,9aR,10aS,10bR,10cR)-8-(3-furyl)-2a,5a,6a,7-tetramethyl-2,5-dioxo-2a,5a,6,6a,8,9,9a,10a,10b,10c-decahydro-2H,5H-cyclopenta[b]furo[2′,3′,4′:4,5]naphtho[2,3-d]furan-6-yl]acetate
methyl [(2aR,5aR,6S,6aR,8R,9aR,10aS,10bR,10cR)-8-(furan-3-yl)-2a,5a,6a,7-tetramethyl-2,5-dioxo-2a,5a,6,6a,8,9,9a,10a,10b,10c-decahydro-2H,5H-cyclopenta[d]naphtho[2,3-b:1,8-b’c’]difuran-6-yl]acetate
Methyl-[(2aR,5aR,6S,6aR,8R,9aR,10aS,10bR,10cR)-8-(3-furyl)-2a,5a,6a,7-tetramethyl-2,5-dioxo-2a,5a,6,6a,8,9,9a,10a,10b,10c-decahydro-2H,5H-cyclopenta[b]furo[2′,3′,4′:4,5]naphtho[2,3-d]furan-6-yl]acetat [German] [ACD/IUPAC Name]
nimbolide
Methyl 2-[(1R,2S,4R,6R,9R,10S,11R,15R,18R)-6-(furan-3-yl)-7,9,11,15-tetramethyl-12,16-dioxo-3,17-dioxapentacyclo[9.6.1.02,9.04,8.015,18]octadeca-7,13-dien-10-yl]acetate

SMILES

CC1=C2[[email protected]@H](C[[email protected]]1c3ccoc3)O[[email protected]]4[[email protected]@]2([[email protected]@H]([[email protected]@]5([[email protected]]6[[email protected]]4OC(=O)[[email protected]@]6(C=CC5=O)C)C)CC(=O)OC)C

StdInChI

InChI=1S/C27H30O7/c1-13-15(14-7-9-32-12-14)10-16-20(13)27(4)17(11-19(29)31-5)26(3)18(28)6-8-25(2)22(26)21(23(27)33-16)34-24(25)30/h6-9,12,15-17,21-23H,10-11H2,1-5H3/t15-,16-,17-,21-,22+,23-,25-,26+,27-/m1/s1

StdInChIKey

JZIQWNPPBKFOPT-LSYMHUITSA-N

Molecular Formula

C27H30O7

Molecular Weight

466.523

Properties

Appearance

Light beige to pure yellow solid

Safety Data

RIDADR 

NONH for all modes of transport

WGK Germany

3

Specifications and Other Information of Our Nimbolide CAS 25990-37-8

Identification Methods

HNMR, HPLC

Purity

98% min

Shelf Life

2 years

Storage

Hygroscopic, -20°C Freezer, Under Inert Atmosphere

Known Application

Nimbolide, a natural triterpenoid present in the edible parts of the neem tree (Azadirachta indica), was found to be growth-inhibitory in human colon carcinoma HT-29 cells. Nimbolide treatment of cells at 2.5 – 10 μM resulted in moderate to very strong growth inhibition.

This product is developed by our R&D company Ulcho Biochemical Ltd (http://www.ulcho.com/).

This product is developed by our R&D company Watson International Ltd (https://www.watson-int.com/).