Melphalan CAS 148-82-3
Identification
CAS Number
148-82-3
Name
Melphalan
Synonyms
(2S)-2-Amino-3-{4-[bis(2-chlorethyl)amino]phenyl}propansäure
(2S)-2-amino-3-{4-[bis(2-chloroethyl)amino]phenyl}propanoic acid
{3-[p-[Bis(2-chloroethyl)amino]phenyl]-L-alanine}
{L-3-[p-[Bis(2-chloroethyl)amino]phenyl]alanine}
3-[p-[Bis(2-chloroethyl)amino]phenyl]-L-alanine
3025 C.B.
4-[Bis(2-chlorethyl)amino]-L-phenylalanin
4-[Bis(2-chloroethyl)amino]-L-phenylalanine
acide (2S)-2-amino-3-{4-[bis(2-chloroéthyl)amino]phényl}propanoïque
D-Sarcolysine
L-3-[p-[Bis(2-chloroethyl)amino]phenyl]alanine
L-Phenylalanine, 4-(bis(2-chloroethyl)amino)-
L-Phenylalanine, 4-[bis(2-chloroethyl)amino]-
Melphalan
melphalanum
p-Di(2-chloroethyl)amino-L-phenylalanine
Sarcoclorin
(S)-2-amino-3-(4-(bis(2-chloroethyl)amino)phenyl)propanoic acid
(S)-2-Amino-3-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-propionic acid
2-Amino-3-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-propionic acid
3-(p-(bis(2-chloroethyl)amino)phenyl)-L-alanine
3-p-(Di(2-chloroethyl)amino)-phenyl-L-alanine
4-(BIS(2-CHLOROETHYL)AMINO)-L-PHENYLALANINE
Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-, L-
Alanine, 3-[p-[bis(2-chloroethyl)amino]phenyl]-, L-
Alanine, 3-[p-[bis(2-chloroethyl)amino]phenyl]-monohydrochloride, L-
Alkeran;L-Phenylalanine mustard;L-PAM
L-3-(p-(bis(2-chloroethyl)amino)phenyl)alanine
L-3-(para-(Bis(2-chloroethyl)amino)phenyl)alanine
Levofalan
Levofolan
Levopholan
L-PAM
L-Phenylalanine mustard
L-SARCOLYSIN
L-sarcolysine
Medphalan
MELFALAN
melfalano
melfalano; melphalan; melphalanum
melphalanum
merphalan
p-Bis(β-chloroethyl)aminophenylalanine
p-Di-(2-chloroethyl)amino-L-phenylalanine
PHENYLALANINE MUSTARD
PHENYLALANINE NITROGEN MUSTARD
p-L-Sarcolysin
p-N,N-bis(2-chloroethyl)amino-L-phenylalanine
p-N-bis(2-chloroethyl)amino-L-phenylalanine
Sarcolysine
Molecular Structure
SMILES
c1cc(ccc1C[C@@H](C(=O)O)N)N(CCCl)CCCl
StdInChI
InChI=1S/C13H18Cl2N2O2/c14-5-7-17(8-6-15)11-3-1-10(2-4-11)9-12(16)13(18)19/h1-4,12H,5-9,16H2,(H,18,19)/t12-/m0/s1
StdInChIKey
SGDBTWWWUNNDEQ-LBPRGKRZSA-N
Molecular Formula
C13H18Cl2N2O2
Molecular Weight
305.20
EINECS
205-726-3
MDL Number
MFCD00057717
Beilstein Registry Number
2816456
Properties
Appearance
White to almost white powder
Melting Point
177ºC
Solubility
Practically insoluble in water, slightly soluble in methanol. It dissolves in dilute mineral acid
Safety Data
Symbol
GHS06, GHS08
Signal Word
Danger
Hazard Statements
Precautionary Statements
P201-P260-P264-P280-P284-P302 + P350
Personal Protective Equipment
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Hazard Codes (Europe)
Risk Statements (Europe)
Safety Statements (Europe)
53-22-36/37/39-45
RIDADR
UN 2811 6.1/PG 2
WGK Germany
3
RTECS
AY3675000
Specifications and Other Information of Our Melphalan CAS 148-82-3
Standard
EP7.5
Assay
94.0%-102.0%
Identification Method
IR
Appearance Of Solution
Clear and colourless
Specific Optical Rotation
-30°~-36°
Water
5.0% max
Sulphated Ash
0.1% max
Diethylamine
0.5% max
Related Substances
Impurity D: 3.0% max
Impurity G: 1.0% max
Impurity J: 0.5% max
Impurity H: 0.5% max
Impurity B: 0.3% max
Impurity I: 0.2% max
Unspecified Impurities: 0.1% max
Total Impurities: 5.5% max
Known Application
Melphalan is an antineoplastic agent.It forms DNA intrastrand crosslinks by bifunctional alkylation in 5′-GGC sequences.
Productivity
5kg/month
Storage
Sealed under dry, cool place away from light and 2 ~ 8℃ for long time storage.