Linagliptin CAS 668270-12-0

Identification

CAS Number

668270-12-0

Name

Linagliptin

Synonyms

8-[(3R)-3-Amino-1-piperidinyl]-7-(2-butin-1-yl)-3-methyl-1-[(4-methyl-2-chinazolinyl)methyl]-3,7-dihydro-1H-purin-2,6-dion [German] [ACD/IUPAC Name]
8-[(3R)-3-Amino-1-piperidinyl]-7-(2-butyn-1-yl)-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]-3,7-dihydro-1H-purine-2,6-dione [ACD/IUPAC Name]
8-[(3R)-3-Amino-1-pipéridinyl]-7-(2-butyn-1-yl)-3-méthyl-1-[(4-méthyl-2-quinazolinyl)méthyl]-3,7-dihydro-1H-purine-2,6-dione [French] [ACD/IUPAC Name]
Linagliptin [Wiki] [INN] [USAN]
(R)-8-(3-aminopiperidin-1-yl)-7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-3,7-dihydro-1H-purine-2,6-dione
(R)-8-(3-aminopiperidin-1-yl)-7-(but-2-ynyl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-1H-purine-2,6(3H,7H)-dione
(R)-8-(3-aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methylquinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione
[668270-12-0]
1H-Purine-2,6-dione, 8-[(3R)-3-amino-1-piperidinyl]-7-(2-butyn-1-yl)-3,7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]- [ACD/Index Name]
356
3X29ZEJ4R2
668270-11-9 [RN]
668270-12-0 [RN]
8-[(3R)-3-Amino-1-piperidinyl]-7-(2-butyn-1-yl)-3,7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]-1H-purine-2,6-dione
8-[(3R)-3-Amino-1-piperidinyl]-7-(2-butynyl)-3,7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]-1H-purine-2,6-dione
8-[(3R)-3-amino-1-piperidyl]-7-but-2-ynyl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]purine-2,6-dione
8-[(3R)-3-aminopiperidin-1-yl]-7-(but-2-yn-1-yl)-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-2,3,6,7-tetrahydro-1H-purine-2,6-dione
8-[(3R)-3-aminopiperidin-1-yl]-7-(but-2-yn-1-yl)-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-3,7-dihydro-1H-purine-2,6-dione
8-[(3r)-3-Aminopiperidin-1-Yl]-7-But-2-Yn-1-Yl-3-Methyl-1-[(4-Methylquinazolin-2-Yl)methyl]-3,7-Dihydro-1h-Purine-2,6-Dione
8-[(3R)-3-aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]purine-2,6-dione
BI 1356
BI 1356;Tradjenta;BI-1356;BI1356
BI1356
BI-1356; Trajenta
Linagliptin (BI-1356)
Linagliptin S-Isomer
MFCD14635356 [MDL number]
Ondero
Tradjenta
Tradjenta®
Trajenta
UNII:3X29ZEJ4R2
UNII-3X29ZEJ4R2

Molecular Structure

SMILES

CC#CCn1c2c(nc1N3CCC[[email protected]](C3)N)n(c(=O)n(c2=O)Cc4nc(c5ccccc5n4)C)C

StdInChI

InChI=1S/C25H28N8O2/c1-4-5-13-32-21-22(29-24(32)31-12-8-9-17(26)14-31)30(3)25(35)33(23(21)34)15-20-27-16(2)18-10-6-7-11-19(18)28-20/h6-7,10-11,17H,8-9,12-15,26H2,1-3H3/t17-/m1/s1

StdInChIKey

LTXREWYXXSTFRX-QGZVFWFLSA-N

Molecular Formula

C25H28N8O2

Molecular Weight

472.542 

MDL Number

MFCD14635356

Properties

Appearance

Off-white to light-yellow crystalline powder

Melting Point

200.0℃~206℃

Safety Data

Specifications and Other Information of Our Linagliptin CAS 668270-12-0

Identification Methods

HPLC

Assay

98%~102%

Residual Solvents

Methanol

≤3000ppm

Isopropanol

≤5000ppm

DMF

≤800ppm

Dichloromethane

≤600ppm

Heavy Metals

≤10ppm

Related Substance

Max single impurity

≤0.1%

Total impurities

≤1.0%

Loss on Drying

≤1.0%

Residue on Ignition

≤0.1%

Isomer

≤0.15%

Shelf Life

2 years

Storage

Under room temperature away from light

Known Application

Lilacitin is used to improve the control of blood glucose levels in people with type 2 diabetes by inhibiting dipeptidyl peptidase-4 (DPP-4) in combination with diet and exercise.

This product is developed by our sub R&D company Caming Pharmaceutical Ltd, and please click the link below for details. http://www.caming.com/linagliptin-cas-668270-12-0/ This product is sold exclusively through our sales company Watson International Ltd, and please click the link below for details. http://www.watson-int.com/linagliptin-cas-668270-12-0/
Posted in APIs, Caming Pharmaceutical Ltd, Products