Structure of GeneticinG418 Sulphate CAS 108321-42-2

Geneticin/G418 Sulphate CAS 108321-42-2

  • Identification
  • Properties
  • Safety Data
  • Specifications & Other Information
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    • Identification

    CAS Number

    108321-42-2

    Name

    Geneticin/G418 Sulphate

    Synonyms

    (1S,2S,3R,4S,6R)-4,6-Diamino-3-({(5R)-2-amino-2-deoxy-5-[(1R)-1-hydroxyethyl]-α-D-xylopyranosyl}oxy)-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranoside sulfate (1:2)
    [ACD/IUPAC Name]
    (1S,2S,3R,4S,6R)-4,6-Diamino-3-({(5R)-2-amino-2-desoxy-5-[(1R)-1-hydroxyethyl]-α-D-xylopyranosyl}oxy)-2-hydroxycyclohexyl-3-desoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosidsulfat (1:2)
    [German]
    [ACD/IUPAC Name]
    108321-42-2
    [RN]
    3-Désoxy-4-C-méthyl-3-(méthylamino)-β-L-arabinopyranoside de (1S,2S,3R,4S,6R)-4,6-diamino-3-({(5R)-2-amino-2-désoxy-5-[(1R)-1-hydroxyéthyl]-α-D-xylopyranosyl}oxy)-2-hydroxycyclohexyle sulfate ( 1:2)
    [French]
    [ACD/IUPAC Name]
    D-glycero-α-D-gluco-Heptopyranoside, (1R,2S,3S,4R,6S)-4,6-diamino-3-[[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl]oxy]-2-hydroxycyclohexyl 2-amino-2,7-dideoxy-, sulfate (1:2) (salt)
    [ACD/Index Name]
    G-418 sulfate
    G418 disulfate
    G418 disulfate salt
    Gentamicin disulfate
    Unverified
    (2R,3R,4R,5R)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-[(1R)-1-hydroxyethyl]oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol and sulfuric acid
    (2R,3R,4R,5R)-2-{[(1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-[(1R)-1-hydroxyethyl]oxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-5-methyl-4-(methylamino)oxane-3,5-diol; bis(sulfuric acid)
    (2R,3S,4R,5R,6S)-5-Amino-6-(((1R,2S,3S,4R,6S)-4,6-diamino-3-(((2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)tetrahydro-2H-pyran-2-yl)oxy)-2-hydroxycyclohexyl)oxy)-2-((R)-1-hydroxyethyl)tetrahydro-2H-pyran-3,4-diol bis(sulfate)
    (2R,3S,4R,5R,6S)-5-AMINO-6-{[(1R,2S,3S,4R,6S)-4,6-DIAMINO-3-{[(2R,3R,4R,5R)-3,5-DIHYDROXY-5-METHYL-4-(METHYLAMINO)OXAN-2-YL]OXY}-2-HYDROXYCYCLOHEXYL]OXY}-2-[(1R)-1-HYDROXYETHYL]OXANE-3,4-DIOL
    49662-05-7
    [RN]
    Antibiotic G-418 sulfate
    Antibiotic G-418, sulfate (salt)
    BIS(SULFURIC ACID)
    G-418 (disulfate)
    G-418 (sulfate)
    G-418 disulfate
    G-418 Disulphate
    G418 disulfate, Cell Culture Reagent
    G418 sulfate
    G418Disulfate
    G418sulfate
    Geneticin
    Geneticin disulfate
    Geneticin sulfate
    Geneticin sulfate;Gentamicin sulfate;Antibiotic G-418 sulfate
    Gentamicin sulfate
    MFCD28168024
    [MDL number]

    SMILES

    CN[C@@H]1C@@HC@@HO)C@@HC@H[C@H]3N)C@@HC[C@H]2N)OC[C@]1(C)O.O=S(=O)(O)O.O=S(=O)(O)O

    StdInChI

    InChI=1S/C20H40N4O10.2H2O4S/c1-6(25)14-11(27)10(26)9(23)18(32-14)33-15-7(21)4-8(22)16(12(15)28)34-19-13(29)17(24-3)20(2,30)5-31-19;21-5(2,3)4/h6-19,24-30H,4-5,21-23H2,1-3H3;2(H2,1,2,3,4)/t6-,7+,8-,9-,10-,11+,12+,13-,14-,15-,16+,17-,18-,19-,20+;;/m1../s1

    StdInChIKey

    UHEPSJJJMTWUCP-DHDYTCSHSA-N

    Molecular Formula

    C20H44N4O18S2

    Molecular Weight

    692.702

    MDL Number

    MFCD28168024

    Properties

    Appearance

    White powder

    Safety Data

    Symbol

    exclamation-mark-jpgGHS08

    Signal Word

    Danger

    Hazard statements

    H317,H334

    Precautionary Statements

    P261 – P272 – P280 – P284 – P302 + P352 – P333 + P313

    RIDADR 

    NONH for all modes of transport

    WGK Germany

    3

    MSDS Download

    GeneticinG418 Sulphate CAS 108321-42-2 SDSDownload

    Specifications and Other Information of Our Geneticin/G418 Sulphate CAS 108321-42-2

    Identification Methods

    HNMR, HPLC

    Solubility (Turbidity)100mg/Ml In H₂O

    Clear to very slightly hazy

    Purity

    ≥95%

    Biological Assay

    ED50 Resistant: ≥2500µg/mL; ED50 Sensitive: ≤400µg/mL

    Absorbance

    1mg/ml H2O: 280nm<0.015; 100mg/ml H2O: 570nm<0.10

    PH

    4.6-6.0

    Heavy Metals

    ≤20ppm

    Water

    <10%

    Potency (On A Dry Basis)

    ≥720µg/mg

    Shelf Life

    2 years

    Storage

    Store at 2­8 °C for long time; in container tightly sealed; Protect from light.

    Known Application

    Geneticin (G418 Sulfate), an aminoglycoside antibiotic, is an inhibitor of 80 S ribosomes extension. It can block polypeptide synthesis by inhibiting the extension step in both prokaryotic and eukaryotic cells. It blocks polypeptide synthesis by interfering with ribosome function. It is not a commonly used standard antibiotic, but is often used to select prokaryotic and eukaryotic cells transfected with neomycin resistance genes. It is widely used in gene transfer, gene knockout, resistance screening, and transgenic animals.

    This product is developed by our R&D company Ulcho Biochemical Ltd (http://www.ulcho.com/).

    This product is developed by our R&D company Watson International Ltd (https://www.watson-int.com/).