Structure of Colistimethate Sodium CAS 8068-37-9(8068-28-8)

Colistimethate Sodium CAS 8068-37-9(8068-28-8)

Identification
Properties
Safety Data
Specifications & Other Information
Links

Identification

CAS Number

8068-37-9(8068-28-8)

Name

Colistimethate Sodium

Synonyms

{[(3S)-4-{[(3S,6S,9S,12S,15R,18S,21S)-3-[(1R)-1-Hydroxyéthyl]-12,15-diisobutyl-2,5,8,11,14,17,20-heptaoxo-6,9,18-tris{2-[(sulfonatométhyl)amino]éthyl}-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]ami no}-3-{[(2S,3R)-3-hydroxy-2-({(2S)-2-{[(6R)-6-méthyloctanoyl]amino}-4-[(sulfonatométhyl)amino]butanoyl}amino)butanoyl]amino}-4-oxobutyl]amino}méthanesulfonate de pentasodium [French] [ACD/IUPAC Name]
2,6,9,14-Tetraazapentadecane-1,15-disulfonic acid, 8-[(1R)-1-hydroxyethyl]-5-[[[(3S,6S,9S,12S,15R,18S,21S)-3-[(1R)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-6,9,18-tris[2-[( sulfomethyl)amino]ethyl]-1,4,7,10,13,16,19-heptaazacyclotricos-21-yl]amino]carbonyl]-11-[[(6R)-6-methyl-1-oxooctyl]amino]-7,10-dioxo-, sodium salt, (5S,8S,11S)- (1:5) [ACD/Index Name]
colistin A sodium methanesulfonate
colistin A sulfomethate sodium
Pentanatrium-{[(3S)-4-{[(3S,6S,9S,12S,15R,18S,21S)-3-[(1R)-1-hydroxyethyl]-12,15-diisobutyl-2,5,8,11,14,17,20-heptaoxo-6,9,18-tris{2-[(sulfonatomethyl)amino]ethyl}-1,4,7,10,13,16,19-heptaazacyclotrico san-21-yl]amino}-3-{[(2S,3R)-3-hydroxy-2-({(2S)-2-{[(6R)-6-methyloctanoyl]amino}-4-[(sulfonatomethyl)amino]butanoyl}amino)butanoyl]amino}-4-oxobutyl]amino}methansulfonat [German] [ACD/IUPAC Name]
Pentasodium {[(3S)-4-{[(3S,6S,9S,12S,15R,18S,21S)-3-[(1R)-1-hydroxyethyl]-12,15-diisobutyl-2,5,8,11,14,17,20-heptaoxo-6,9,18-tris{2-[(sulfonatomethyl)amino]ethyl}-1,4,7,10,13,16,19-heptaazacyclotricos an-21-yl]amino}-3-{[(2S,3R)-3-hydroxy-2-({(2S)-2-{[(6R)-6-methyloctanoyl]amino}-4-[(sulfonatomethyl)amino]butanoyl}amino)butanoyl]amino}-4-oxobutyl]amino}methanesulfonate [ACD/IUPAC Name]
polymyxin E1 sodium methanesulfonate
8068-28-8 [RN]
clotricosan-21-yl]amino}-3-{[(2S,3R)-3-hydroxy-2-({(2S)-2-{[(6R)-6-methyloctanoyl]amino}-4-[(sulfonatomethyl)amino]butanoyl}amino)butanoyl]amino}-4-oxobutyl]amino}methanesulfonate
Colistimethate sodium
colistin A sulfomethate sodiumpolymyxin E1 sodium methanesulfonatepolymyxin E1 sulfomethate sodium
Colistin X
ethyl}-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}-2-methyl-7,10,13-trioxo-19-sulfonato-9-{2-[(sulfonatomethyl)amino]ethyl}-8,11,14,18-tetraazanonadec-1-yl
NOCAS_872303
pentasodium (2S,9S,12S,15S)-12-[(1R)-1-hydroxyethyl]-15-{[(3S,6S,9S,12S,15R,18S,21S)-3-[(1R)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-6,9,18-tris{2-[(sulfonatomethyl)amino]
pentasodium {[(3S)-4-{[(3S,6S,9S,12S,15R,18S,21S)-3-[(1R)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-6,9,18-tris{2-[(sulfonatomethyl)amino]ethyl}-1,4,7,10,13,16,19-heptaazacy
pentasodium {[(3S)-4-{[(3S,6S,9S,12S,15R,18S,21S)-3-[(1R)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-6,9,18-tris{2-[(sulfonatomethyl)amino]ethyl}-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]amino}-3-{[(2S,3R)-3-hydroxy-2-({(2S)-2-{[(6R)-6-methyloctanoyl]amino}-4-[(sulfonatomethyl)amino]butanoyl}amino)butanoyl]amino}-4-oxobutyl]amino}methanesulfonate
polymyxin E1 sulfomethate sodium

Molecular Structure

Structure of Colistimethate Sodium CAS 8068-37-9(8068-28-8)

Structure of Colistimethate Sodium CAS 8068-37-9(8068-28-8)

SMILES

CC[C@@H](C)CCCCC(=O)N[C@@H](CCNCS(=O)(=O)[O-])C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCNCS(=O)(=O)[O-])C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)CCNCS(=O)(=O)[O-])CC(C)C)CC(C)C)CCNCS(=O)(=O)[O-])CCNCS(=O)(=O)[O-])[C@@H](C)O.[Na+].[Na+].[Na+].[Na+].[Na+]

StdInChI

InChI=1S/C58H110N16O28S5.5Na/c1-9-35(6)12-10-11-13-46(77)65-38(14-20-59-28-103(88,89)90)53(82)74-48(37(8)76)58(87)70-41(17-23-62-31-106(97,98)99)50(79)68-43-19-25-64-57(86)47(36(7)75)73-54(83)42(18-24-63-32-107(100,101)102)67-49(78)39(15-21-60-29-104(91,92)93)69-55(84)44(26-33(2)3)72-56(85)45(27-34(4)5)71-52(81)40(66-51(43)80)16-22-61-30-105(94,95)96;;;;;/h33-45,47-48,59-63,75-76H,9-32H2,1-8H3,(H,64,86)(H,65,77)(H,66,80)(H,67,78)(H,68,79)(H,69,84)(H,70,87)(H,71,81)(H,72,85)(H,73,83)(H,74,82)(H,88,89,90)(H,91,92,93)(H,94,95,96)(H,97,98,99)(H,100,101,102);;;;;/q;5*+1/p-5/t35-,36-,37-,38+,39+,40+,41+,42+,43+,44+,45-,47+,48+;;;;;/m1…../s1

StdInChIKey

IQWHCHZFYPIVRV-VLLYEMIKSA-I

Molecular Formula

C58H105N16Na5O28S5

Molecular Weight

1749.81

EINECS

232-516-9

MDL Number

MFCD00130824

Properties

Appearance

White to slightly yellow, odorless, fine powder

Safety Data

Personal Protective Equipment

Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

RIDADR

NONH for all modes of transport

WGK Germany

2

RTECS

GH1650000

Specifications and Other Information of Our Colistimethate Sodium CAS 8068-37-9(8068-28-8)

Standard

USP

Identification Methods

IR

Assay(on the basis)

≥390ug/mg

Bacterial endotoxins

≤2.0EU/mg

Microbial limit

TMAC≤1000cfu/g
TYMC≤100cfu/g

Heavy metal

≤30ppm

Loss on Drying

≤7.0%

Free colistin

No immediate precipitate in formed

pH

6.5-8.5

Package

According to customer requirements to packaging

Storage

Under the room temperature and away from light

Application

Colistimethate sodium is one of the first choices for Pseudomonas aeruginosa infection. It can treat Pseudomonas aeruginosa meningitis and can also be used for sepsis, urinary system, abdomen and other post-operative infections.

Links

This product is developed by our sub R&D company Caming Pharmaceutical Ltd, and please click the link below for details.
http://www.caming.com/colistimethate-sodium-cas-8068-37-98068-28-8/

This product is sold exclusively through our sales company Watson International Ltd, and please click the link below for details.
http://www.watson-int.com/colistimethate-sodium-cas-8068-37-98068-28-8/