Structure of Cefotaxime sodium Sterile CAS 64485-93-4

Cefotaxime Sodium Sterile CAS 64485-93-4

Identification

CAS Number

64485-93-4

Name

Cefotaxime sodium

Synonyms

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)-1-oxoethyl]amino]-8-oxo-, sodium salt, (6R,7R)- (1:1)
Sodium (6R,7R)-3-(acetoxymethyl)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
sodium (6R,7R)-3-[(acetyloxy)methyl]-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
(+)-Cefotaxime Sodium
(+)-Cefotaxime sodium salt
(6R,7R)-3-Acetoxymethyl-7-[2-(2-amino-thiazol-4-yl)-2-methoxyimino-acetylamino]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt
(6R,7R)-3-acetoxymethyl-7-{2-(2-amino-thiazol-4-yl)-2-[(Z)-methoxyimino]-acetylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate
Cefcil
Cefotaxim sodium
Cefotaxim sodium salt
Cefotaxime
Cefotaxime sodium
Cefotaxime Sodium Salt
Cefotaximesodium
CLAFORAN
Claforan
CTX
Pretor
RU-24756
Sodium
sodium 3-(acetoxymethyl)-7β-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-2,3-didehydrocepham-2-carboxylate
sodium 3-(acetoxymethyl)-7β-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3,4-didehydrocepham-4-carboxylate
Sodium 7-(2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamido)cephalosporanate
Sodium cefotaxime
Sodium; (6R,7R)-3-acetoxymethyl-7-{2-(2-amino-thiazol-4-yl)-2-[(Z)-methoxyimino]-acetylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate

Molecular Structure

Structure of Cefotaxime sodium Sterile CAS 64485-93-4

SMILES

[Na+].O=C2N1/C(=C(\CS[C@@H]1[C@@H]2NC(=O)C(=N\OC)/c3nc(sc3)N)COC(=O)C)C([O-])=O

StdInChI

InChI=1S/C16H17N5O7S2.Na/c1-6(22)28-3-7-4-29-14-10(13(24)21(14)11(7)15(25)26)19-12(23)9(20-27-2)8-5-30-16(17)18-8;/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,23)(H,25,26);/q;+1/p-1/b20-9-;/t10-,14-;/m1./s1

SydInChIKey

AZZMGZXNTDTSME-JUZDKLSSSA-M

Molecular Formula

C16H16N5NaO7S2

Molecular Weight

477.44

EINECS Number

264-915-9

MDL Number

MFCD00079073

Beilstein Registry Number

5711411

Properties

Appearance

White to pale yellow crystalline powder

Solubility

H2O: soluble (aqueous solutions of pH 4.3-6.2 are stable up to 3 weeks at 2-8 °C.)

Suitability

Plant cell culture tested

Safety Data

Symbol

health-hazard-jpgGHS08

Signal word

Danger

Hazard Statements

H317-H334

Precautionary Statements

P261-P280-P342+P311

Hazard Codes (Europe)

Xn

Risk Statements (Europe)

42/43

Safety Statements (Europe)

22-36/37

WGK Germany

2

RTECS

XI0250000

Specifications and Other Information of Our Cefotaxime sodium Sterile CAS 64485-93-4

Standard

USP32

Identification

IR Spectrum, HPLC RT, Sodium

Clarity

Clear

Color of Solution

0.2 max(430nm,10% Solution)

Specific Rotation

+56°~+64°

PH

4.5~6.5

Loss on Drying

3.0% max

Individual Impurity

1.0% max

Total impurities

3.0% max

Sterility

Sterile

Bacterial Endotoxins

0.20 USP EU/mg max

Particulate Matter

10um NMT 6000 min
25 um NMT 600 min

Assay(HPLC)

916~964 ug/mg (as Cefotaxime, anhydrous)

Storage

Preserve in tight container, 2-8 °C at dry place, away from light.

Package

5kg/tin,10kg/tin

Known Application

Broad spectrum third generation cephalosporin antibiotic.

Biochem/physiol Actions

Cefotaxim inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. As a result, bacteria lyse due to cell wall autolytic enzymes.
Cefotaxime, a cephalosporin antibiotic, is active against both gram-negative and gram-positive bacteria. In addition, cefotaxime blocks the division of cyanobacteria and lower plant organelles/plastids such as the photosynthetic organelles of Glaucophytes and chloroplasts of bryophytes.

Watson-Int Link

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