Calcium levofolinate CAS 80433-71-2

Identification
Properties
Safety Data
Specifications & Other Information
Links

Identification

CAS Number

80433-71-2

Name

Calcium levofolinate

Synonyms

(2S)-2-{[4-({[(6S)-2-Amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydro-6-ptéridinyl]méthyl}amino)benzoyl]amino}pentanedioate de calcium [French] [ACD/IUPAC Name]
80433-71-2 [RN]
calcii levofolinas [Latin] [INN]
Calcium (2S)-2-{[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydro-6-pteridinyl]methyl}amino)benzoyl]amino}pentanedioate [ACD/IUPAC Name]
Calcium (2S)-2-{[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]amino}pentanedioate
Calcium 2-{[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]amino}pentanedioate
calcium levofolinate [INN]
Calcium N-(p-((((6S)-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamate (1:1)
Calcium-(2S)-2-{[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydro-6-pteridinyl]methyl}amino)benzoyl]amino}pentandioat [German] [ACD/IUPAC Name]
Elvorine [Trade name]
Isovorin [Trade name]
lévofolinate de calcium [French] [INN]
levofolinato de calcio [Spanish] [INN]
LEVOLEUCOVORIN CALCIUM [USAN]
L-Glutamic acid, N-[4-[[[(6S)-2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl]methyl]amino]benzoyl]-, calcium salt (1:1) [ACD/Index Name]
N-[4-[[[(6S)-2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl]methyl]amino]benzoyl]-L-glutamic Acid Calcium Salt (1:1)
кальция левофолинат [Russian] [INN]
ليفوفولينات كالسيوم [Arabic] [INN]
左亚叶酸钙 [Chinese] [INN]
[80433-71-2]
calcium (2S)-2-[[[4-[[(6S)-2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl]methylamino]phenyl]-oxomethyl]amino]pentanedioate
calcium (2S)-2-[[4-[[(6S)-2-amino-5-formyl-4-keto-1,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]glutarate
calcium (2S)-2-[[4-[[(6S)-2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioate
calcium (2S)-2-[[4-[[(6S)-2-amino-5-methanoyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl]methylamino]phenyl]carbonylamino]pentanedioate
Calcium (6S)-folinate
Calcium folinate [INN] [JP15]
Calcium levofolinate;Elvorine;Isovorin;CL307782
CL307782
D04715
Isovorin (TN)
Leucovorin calcium [USP]
Levofolinate calcium
Levofolinate calcium (JAN)
L-Leucovorin Calcium
MFCD08704249 [MDL number]
UNII:778XL6VBS8
UNII-778XL6VBS8
UNII-RPR1R4C0P4

Molecular Structure

Structure of Calcium levofolinate CAS 80433-71-2

Structure of Calcium levofolinate CAS 80433-71-2

SMILES

c1cc(ccc1C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-])NC[C@H]2CNc3c(c(=O)nc([nH]3)N)N2C=O.[Ca+2]

StdInChI

InChI=1S/C20H23N7O7.Ca/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);/q;+2/p-2/t12-,13-;/m0./s1

StdInChIKey

KVUAALJSMIVURS-QNTKWALQSA-L

Molecular Formula

C20H21CaN7O7

Molecular Weight

511.50

Properties

Appearance

White or light yellow amorphous or crystalline powder

Safety Data

Signal Word

Warning

Specifications and Other Information of Our Calcium levofolinate CAS 80433-71-2

Standard

EP6.0

Calcium

7.54%~8.14%

Calcium folinate

97%~102%

Impurity H

≤0.5%

Any other impurity

≤0.8%

Total impurities

≤1.0%

Chlorides

≤0.5%

Specific Optical Rotation

-10.0°~ -15.0°

Heavy Metals

≤50ppm

Water

10%~17%

pH

7.5~8.5

Ethanol

≤30000ppm

Acetone

≤5000ppm

Bacteria endotoxins

≤0.5EU/mg

Package

According to customer requirements to packaging

Shelf life

2 years

Storage

Under the room temperature and away from light

Application

Mainly used for the treatment of gastric cancer and colorectal cancer.

General View of Documents

Calcium levofolinate CAS 80433-71-2 HPLC

Calcium levofolinate CAS 80433-71-2 HPLC

Links

This product is developed by our sub R&D company Caming Pharmaceutical Ltd, and please click the link below for details.
http://www.caming.com/calcium-levofolinate-cas-80433-71-2/

This product is sold exclusively through our sales company Watson International Ltd, and please click the link below for details.
http://www.watson-int.com/calcium-levofolinate-cas-80433-71-2/

Posted in APIs, Caming Pharmaceutical Ltd, Products