Structure of Buserelin CAS# 68630-75-1

Buserelin CAS 68630-75-1

Identification

CAS Number

68630-75-1

Name

Buserelin

Synonyms

5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-O-(2-methyl-2-propanyl)-D-seryl-L-leucyl-L-arginyl-N-ethyl-L-prolinamidacetat (1:1) [German] [ACD/IUPAC Name]
5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-O-(2-methyl-2-propanyl)-D-seryl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide acetate (1:1) [ACD/IUPAC Name]
5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-O-tert-butyl-D-seryl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide acetate (1:1)
68630-75-1 [RN]
Acide acétique – 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-séryl-L-tyrosyl-O-(2-méthyl-2-propanyl)-D-séryl-L-leucyl-L-arginyl-N-éthyl-L-prolinamide (1:1) [French] [ACD/IUPAC Name]
Buserelin acetate [JAN] [USAN]
Buserelin monoacetate
HOE 766MP {Acetate}
L-Prolinamide, 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-O-(1,1-dimethylethyl)-D-seryl-L-leucyl-L-arginyl-N-ethyl-, acetate (1:1) [ACD/Index Name]
(Des-Gly10,D-Ser(tBu)6,Pro-NHEt9)-LHRH
(S)-1-((3S,6S,9S,12S,15R,18S,21S)-3-((1H-imidazol-5-yl)methyl)-6-((1H-indol-3-yl)methyl)-15-(tert-butoxymethyl)-21-(3-((diaminomethylene)amino)propyl)-12-(4-hydroxybenzyl)-9-(hydroxymethyl)-18-isobutyl-1,4,7,10,13,16,19-heptaoxo-1-((S)-5-oxopyrrolidin-2-yl)-2,5,8,11,14,17,20-heptaazadocosan-22-oyl)-N-ethylpyrrolidine-2-carboxamide acetate
[68630-75-1]
1-9-Luteinizing hormone-releasing factor (swine), 6-[O-(1,1- dimethylethyl)-D-serine]-9-(N-ethyl-L-prolinamide)-, monoacetate (salt)
261-061-9 [EINECS]
57982-77-1 [RN]
5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-O-tert-butyl-D-seryl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide monoacetate (salt)
Buserelin acetate (JAN/USAN) [JAN] [USAN]
HOE 766 MP
Hoe-766 MP
MFCD00870371 [MDL number]
MFCD01716229
Suprecur [Trade name]
Suprefact

SMILES

CCNC(=O)[[email protected]@H]1CCCN1C(=O)[[email protected]](CCCNC(=N)N)NC(=O)[[email protected]](CC(C)C)NC(=O)[[email protected]@H](COC(C)(C)C)NC(=O)[[email protected]](Cc2ccc(cc2)O)NC(=O)[[email protected]](CO)NC(=O)[[email protected]](Cc3c[nH]c4c3cccc4)NC(=O)[[email protected]](Cc5cnc[nH]5)NC(=O)[[email protected]@H]6CCC(=O)N6.CC(=O)O

StdInChI

InChI=1S/C60H86N16O13.C2H4O2/c1-7-64-57(87)48-15-11-23-76(48)58(88)41(14-10-22-65-59(61)62)69-51(81)42(24-33(2)3)70-56(86)47(31-89-60(4,5)6)75-52(82)43(25-34-16-18-37(78)19-17-34)71-55(85)46(30-77)74-53(83)44(26-35-28-66-39-13-9-8-12-38(35)39)72-54(84)45(27-36-29-63-32-67-36)73-50(80)40-20-21-49(79)68-40;1-2(3)4/h8-9,12-13,16-19,28-29,32-33,40-48,66,77-78H,7,10-11,14-15,20-27,30-31H2,1-6H3,(H,63,67)(H,64,87)(H,68,79)(H,69,81)(H,70,86)(H,71,85)(H,72,84)(H,73,80)(H,74,83)(H,75,82)(H4,61,62,65);1H3,(H,3,4)/t40-,41-,42-,43-,44-,45-,46-,47+,48-;/m0./s1

StdInChIKey

PYMDEDHDQYLBRT-DRIHCAFSSA-N

Molecular Formula

C62H90N16O15

Molecular Weight

1299.47

MDL Number

MFCD00941414

Properties

Appearance

White or slightly yellowish powder

Safety Data

Symbol

exclamation-mark-jpgexclamation-mark-jpgGHS07,GHS08

Signal Word


Danger

Hazard statements

H302 – H360

Precautionary Statements

P201 – P301 + P312 + P330 – P308 + P313

Personal Protective Equipment

Eyeshields, Faceshields, Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

RIDADR 

NONH for all modes of transport

WGK Germany

3

Specifications and Other Information of Our Buserelin CAS 68630-75-1

Identification Methods

HPLC

Assay

95%~102%

Specific Optical Rotation

-49.0 ~ -58.0°[a] 20 D (c=1, water)

Specific Absorbance(By anhydrous, acetic acid-free)

49~56(278nm)

Water

≤4.0%

Amino Acid Composition

Arg0.9 ~ 1.1
Leu0.9 ~ 1.1
Tyr0.9 ~ 1.1
Glu0.9 ~ 1.1
Pro0.8 ~ 1.2
His0.9 ~ 1.1
Ser1.4 ~ 2.0
TrpDetected

Related Substance (By HPLC)

Single Impurity

≤1.0%

Total Impurities

≤5.0%

Acetate Content (By HPLC)

3~7%

Bacterial Endotoxins

≤55.5 IU/mg

Shelf Life

2 years

Storage

Store at 2~8℃, sealed and away from light.

Known Application

It is often used to treat prostate cancer, breast cancer, endometriosis, uterine fibroids and other diseases. The clinical dosage forms are injections and nasal sprays.

Apnoke Scientific Ltd

This product is developed by our sub R&D company Apnoke Scientific Ltd , and please click the link below for details. http://www.apnoke.com/buserelinacetate-cas-68630-75-1/

Watson International Ltd

This product is sold exclusively through our sales company Watson International Ltd, and please click the link below for details. http://www.watson-int.com/buserelinacetate-cas-68630-75-1/