Bimatoprost CAS 155206-00-1
Identification
Properties
Safety Data
Specifications & Other Information
Links
Identification
CAS Number
155206-00-1
Name
Bimatoprost
Synonyms
(5Z)-7-{(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl}-N-ethyl-5-heptenamid [German] [ACD/IUPAC Name]
(5Z)-7-{(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl}-N-ethyl-5-heptenamide [ACD/IUPAC Name]
(5Z)-7-{(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3S)-3-hydroxy-5-phényl-1-pentén-1-yl]cyclopentyl}-N-éthyl-5-hepténamide [French] [ACD/IUPAC Name]
(5Z)-7-{(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenylpent-1-en-1-yl]cyclopentyl}-N-ethylhept-5-enamide
5-Heptenamide, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl]-N-ethyl-, (5Z)- [ACD/Index Name]
bimatoprost [French] [INN]
bimatoprost [Spanish] [INN]
Bimatoprost [USAN] [Wiki]
bimatoprostum [Latin] [INN]
Lumigan [Trade name]
биматопрост [Russian] [INN]
بيماتوبروست [Arabic] [INN]
贝美前列素 [Chinese] [INN]
(5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenylpent-1-en-1-yl]cyclopentyl]-N-ethylhept-5-enamide
(Z)-7-((1R,2R,3R,5S)-3,5-Dihydroxy-2-((1E,3S)-3-hydroxy-5-phenyl-1-pentenyl)cyclopentyl)-N-ethyl-5-heptenamide
(Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-5-phenylpent-1-en-1-yl)cyclopentyl)-N-ethylhept-5-enamide
(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-enyl]cyclopentyl]-N-ethylhept-5-enamide
(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxy-5-phenyl-pent-1-enyl]cyclopentyl]-N-ethyl-hept-5-enamide
[155206-00-1]
155206-00-1 [RN]
267244-98-4 [RN]
5-Heptenamide, 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((1E,3S)-3-hydroxy-5-phenyl-1-pentenyl)cyclopentyl)-N-ethyl-, (5Z)-
5-Heptenamide, 7-(3,5-dihydroxy-2-(3-hydrdoxy-5-phenyl-1-pentenyl)cyclopentyl)-N-ethyl-, (1R-(1α(Z),2β(1E,3S*),3α,5α))-
AGN 192024|LS-181817|Lumigan®
Lumigan (TN)
Lumigan®
Lumigan; Latisse; AGN 192024; bimatoprostum; Lumigan (TN); AC1NSJUW; AGN-192024; UNII-QXS94885MZ
MFCD03411999 [MDL number]
UNII-QXS94885MZ
Molecular Structure
SMILES
CCNC(=O)CCC/C=C\C[C@H]1[C@H](C[C@H]([C@@H]1/C=C/[C@H](CCc2ccccc2)O)O)O
StdInChI
InChI=1S/C25H37NO4/c1-2-26-25(30)13-9-4-3-8-12-21-22(24(29)18-23(21)28)17-16-20(27)15-14-19-10-6-5-7-11-19/h3,5-8,10-11,16-17,20-24,27-29H,2,4,9,12-15,18H2,1H3,(H,26,30)/b8-3-,17-16+/t20-,21+,22+,23-,24+/m0/s1
StdInChIKey
AQOKCDNYWBIDND-FTOWTWDKSA-N
Molecular Formula
C25H37NO4
Molecular Weight
415.57
Properties
Appearance
White powder
Safety Data
Personal Protective Equipment
Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RIDADR
NONH for all modes of transport
WGK Germany
3
MSDS
MSDS of Bimatoprost CAS 155206-00-1
Specifications and Other Information of Our Bimatoprost CAS 155206-00-1
Standard
Enterprise standard
Certificate
GMP
Identification Methods
HNMR/HPLC
Purity
99.5% min
Specific Optical Rotation
+33.0-+37.0°
Heavy Metals
10ppmmax
Residue on Ignition
0.1%max
Single Impurity
0.1%max
Total Impurities
0.5%max
Description
Bimatoprostophthalmic solution 0.01% and 0.03% is a synthetic prostamide analog with ocular hypotensive activity; is aclear, isotonic,colorless sterile ophthalmic solution with an osmolalityof approximately 290 mOsmol/kg.
Adding proportion for reference
Bimatoprostophthalmic solution: 0.01% contains Active:
bimatoprost 0.1 mg/mL;
Preservative:benzalkonium chloride 0.2mg/ml;
Inactives: sodium chloride; sodium phosphatedibasic;citric acid;and purified water.
Sodium hydroxide and/or hydrochloric acid may be added to adjust pH. The pH during its shelf life ranges from 6.8-7.8.
Bimatoprostophthalmic solution: 0.03% contains Active:
bimatoprost: 0.3 mg/mL;
Preservative:benzalkonium chloride: 0.05 mg/mL;
Inactives: sodium chloride; sodium phosphate,dibasic; citric acid;and purified water.
Sodium hydroxide and/or hydrochloric acid may be added to adjust pH. The pH during its shelf life rangesfrom 6.8-7.8.
Storage
Store at the 2-8℃
Application
Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. It reduces intraocular pressure (IOP) by increasing the outflow of aqueous fluid from the eyes. It has also been used and prescribed off-label to lengthen eyelashes.
General View of Documents
Normal Phase HPLC of Bimatoprost CAS 155206-00-1
Reverse Phase HPLC of Bimatoprost CAS 155206-00-1
Links
Caming Pharmaceutical Ltd
This product is developed by our sub R&D company Caming Pharmaceutical Ltd, and please click the link below for details.
http://www.caming.com/bimatoprost-cas-155206-00-1/
Watson International Ltd
This product is sold exclusively through our sales company Watson International Ltd, and please click the link below for details.
http://www.watson-int.com/bimatoprost-cas-155206-00-1/
