Structure of Beta-AmyloidPeptide(1-42),CAS 107761-42-2

Beta-AmyloidPeptide(1-42),CAS 107761-42-2

Identification

CAS Number

107761-42-2

Name

Beta-AmyloidPeptide(1-42)

Peptide sequence

Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala

Synonyms

107761-42-2 [RN]
Human β-amyloid peptide (1-42)
β-amyloid 42
β-amyloid polypeptide 42
β-amyloid protein 42
??-Amyloid(1-42) Human
[107761-42-2]
Amyloid β-Peptide (1-42) (human)
amyloid-β polypeptide 42
Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:64647
L-α-aspartyl-L-alanyl-L-α-glutamyl-L-phenylalanyl-L-arginyl-L-histidyl-L-α-aspartyl-L-serylglycyl-L-tyrosyl-L-α-glutamyl-L-valyl-L-histidyl-L-histidyl-L-glutaminyl-L-lysyl-L-leucyl-L-valyl-L-phenylalanyl-L-phenylalanyl-L-alanyl-L-α-glutamyl-L-α-aspartyl-L-valylglycyl-L-seryl-L-asparaginyl-L-lysylglycyl-L-alanyl-L-isoleucyl-L-isoleucylglycyl-L-leucyl-L-methionyl-L-valylglycylglycyl-L-valyl-L-valyl-L-isoleucyl-L-alanine
MFCD01864012
Not available
β-amyloid(1-42) human

SMILES

[H]/N=C(\N)/NCCC[[email protected]@H](C(=O)N[[email protected]@H](Cc1cnc[nH]1)C(=O)N[[email protected]@H](CC(=O)O)C(=O)N[[email protected]@H](CO)C(=O)NCC(=O)N[[email protected]@H](Cc2ccc(cc2)O)C(=O)N[[email protected]@H](CCC(=O)O)C(=O)N[[email protected]@H](C(C)C)C(=O)N[[email protected]@H](Cc3cnc[nH]3)C(=O)N[[email protected]@H](Cc4cnc[nH]4)C(=O)N[[email protected]@H](CCC(=O)N)C(=O)N[[email protected]@H](CCCCN)C(=O)N[[email protected]@H](CC(C)C)C(=O)N[[email protected]@H](C(C)C)C(=O)N[[email protected]@H](Cc5ccccc5)C(=O)N[[email protected]@H](Cc6ccccc6)C(=O)N[[email protected]@H](C)C(=O)N[[email protected]@H](CCC(=O)O)C(=O)N[[email protected]@H](CC(=O)O)C(=O)N[[email protected]@H](C(C)C)C(=O)NCC(=O)N[[email protected]@H](CO)C(=O)N[[email protected]@H](CC(=O)N)C(=O)N[[email protected]@H](CCCCN)C(=O)NCC(=O)N[[email protected]@H](C)C(=O)N[[email protected]@H]([[email protected]@H](C)CC)C(=O)N[[email protected]@H]([[email protected]@H](C)CC)C(=O)NCC(=O)N[[email protected]@H](CC(C)C)C(=O)N[[email protected]@H](CCSC)C(=O)N[[email protected]@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[[email protected]@H](C(C)C)C(=O)N[[email protected]@H](C(C)C)C(=O)N[[email protected]@H]([[email protected]@H](C)CC)C(=O)N[[email protected]@H](C)C(=O)O)NC(=O)[[email protected]](Cc7ccccc7)NC(=O)[[email protected]](CCC(=O)O)NC(=O)[[email protected]](C)NC(=O)[[email protected]](CC(=O)O)N

StdInChI

InChI=1S/C203H311N55O60S/c1-28-106(20)164(195(310)220-91-149(267)228-130(71-98(4)5)181(296)238-129(66-70-319-27)179(294)251-158(100(8)9)193(308)218-87-146(264)215-88-151(269)250-160(102(12)13)198(313)255-163(105(18)19)199(314)258-165(107(21)29-2)200(315)227-112(26)202(317)318)257-201(316)166(108(22)30-3)256-169(284)109(23)224-147(265)89-216-171(286)122(51-40-42-67-204)233-188(303)139(81-145(208)263)244-192(307)143(94-260)230-150(268)92-219-194(309)159(101(10)11)252-191(306)141(83-157(280)281)245-177(292)127(60-64-153(272)273)232-168(283)111(25)226-180(295)133(73-113-45-34-31-35-46-113)241-184(299)135(75-115-49-38-33-39-50-115)247-196(311)162(104(16)17)254-190(305)131(72-99(6)7)239-173(288)123(52-41-43-68-205)234-175(290)125(58-62-144(207)262)236-185(300)136(77-117-84-211-95-221-117)243-187(302)138(79-119-86-213-97-223-119)248-197(312)161(103(14)15)253-178(293)128(61-65-154(274)275)237-182(297)132(76-116-54-56-120(261)57-55-116)229-148(266)90-217-172(287)142(93-259)249-189(304)140(82-156(278)279)246-186(301)137(78-118-85-212-96-222-118)242-174(289)124(53-44-69-214-203(209)210)235-183(298)134(74-114-47-36-32-37-48-114)240-176(291)126(59-63-152(270)271)231-167(282)110(24)225-170(285)121(206)80-155(276)277/h31-39,45-50,54-57,84-86,95-112,121-143,158-166,259-261H,28-30,40-44,51-53,58-83,87-94,204-206H2,1-27H3,(H2,207,262)(H2,208,263)(H,211,221)(H,212,222)(H,213,223)(H,215,264)(H,216,286)(H,217,287)(H,218,308)(H,219,309)(H,220,310)(H,224,265)(H,225,285)(H,226,295)(H,227,315)(H,228,267)(H,229,266)(H,230,268)(H,231,282)(H,232,283)(H,233,303)(H,234,290)(H,235,298)(H,236,300)(H,237,297)(H,238,296)(H,239,288)(H,240,291)(H,241,299)(H,242,289)(H,243,302)(H,244,307)(H,245,292)(H,246,301)(H,247,311)(H,248,312)(H,249,304)(H,250,269)(H,251,294)(H,252,306)(H,253,293)(H,254,305)(H,255,313)(H,256,284)(H,257,316)(H,258,314)(H,270,271)(H,272,273)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,317,318)(H4,209,210,214)/t106-,107-,108-,109-,110-,111-,112-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,158-,159-,160-,161-,162-,163-,164-,165-,166-/m0/s1

StdInChIKey

DZHSAHHDTRWUTF-SIQRNXPUSA-N

Molecular Formula

C203H311N55O60S

Molecular Weight

4514.04

MDL Number

MFCD00163049

Properties

Appearance

White powder

Safety Data

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR 

NONH for all modes of transport

WGK Germany

3

Specifications and Other Information of Our Beta-AmyloidPeptide(1-42),CAS 107761-42-2

Identification Methods

HNMR, HPLC

Purity

98% min

Absorption coefficient

1280 M-1cm-1  

PI,isoelectric point

pH 5.17  

Net charge at pH 7

-2.7 

Solubility evaluation

Poor water solubility

Toxicity mechanism of Amyloid oligomer

  1. The effect on oxidative stress. Aβ can induce oxidative stress, produce a large number of free radicals, and then produce oxidative stress on neurons.
  2. Cause Ca2+ disorder. Aβ destroys the K+ channel on the cell membrane, causing a large amount of Ca2+ influx.
  3. Interaction with receptors on the cell membrane surface. Amyloid oligomers can activate excitatory NMDA2RS receptors, causing mitochondrial disorders and neuronal death.
  4. Amyloid in cells is also an important pathological feature. A large number of oligomers in the cells cause pathology. The production and degradation of Amyloid secreted by normal cells is relatively balanced.
  5. Break the balance between Bax and Bel-2.

Shelf Life

2 years

Storage

Store at -20°C or -80°C for long time, Sealed and away from light

Known Application

Often used to study Alzheimer’s disease.

Apnoke Scientific Ltd

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Watson International Ltd

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