Structure of Beta-Amyloid(25-35) CAS 131602-53-4

Beta-Amyloid(25-35) CAS 131602-53-4

Identification

CAS Number

131602-53-4

Name

Beta-Amyloid(25-35)

Peptide sequence

Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met

Synonyms

131602-53-4 [RN]
amyloid β-peptide(25-35)
Glycyl-L-seryl-L-asparaginyl-L-lysylglycyl-L-alanyl-L-isoleucyl-L-isoleucylglycyl-L-leucyl-L-methionin [German] [ACD/IUPAC Name]
Glycyl-L-seryl-L-asparaginyl-L-lysylglycyl-L-alanyl-L-isoleucyl-L-isoleucylglycyl-L-leucyl-L-methionine [ACD/IUPAC Name]
Glycyl-L-séryl-L-asparaginyl-L-lysylglycyl-L-alanyl-L-isoleucyl-L-isoleucylglycyl-L-leucyl-L-méthionine [French] [ACD/IUPAC Name]
L-Methionine, glycyl-L-seryl-L-asparaginyl-L-lysylglycyl-L-alanyl-L-isoleucyl-L-isoleucylglycyl-L-leucyl- [ACD/Index Name]
(2S)-2-[[(2S)-2-[[2-[[(2S,3S)-2-[[(2S,3S)-2-[[(2S)-2-[[2-[[(2S)-6-amino-2-[[(2S)-4-amino-2-[[(2S)-2-[(2-aminoacetyl)amino]-3-hydroxypropanoyl]amino]-4-oxobutanoyl]amino]hexanoyl]amino]acetyl]amino]propanoyl]amino]-3-methylpentanoyl]amino]-3-methylpentanoyl]amino]acetyl]amino]-4-methylpentanoyl]amino]-4-methylsulfanylbutanoic acid
[131602-53-4]
Å-Amyloid (25-35)
Amyloid b (25-35)
Amyloid β-peptide (25-35) (human)
Amyloid-�� Peptide (25-35), Human
Amyloid β Protein fragment 25-35
Amyloid β-peptide (25-35) (human)
amyloid β-protein (25-35)
amyloid β-protein fragment 25-35
amyloidβpeptide(25-35),human
BU7435200
Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met
H-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-OH
L-Methionine,glycyl-L-seryl-L-asparaginyl-L-lysylglycyl-L-alanyl-L-isoleucyl-L-isoleucylglycyl-L-leucyl-
MFCD00133076
β-AMYLOID (25-35)

SMILES

CC[[email protected]](C)[[email protected]@H](C(=O)N[[email protected]@H]([[email protected]@H](C)CC)C(=O)NCC(=O)N[[email protected]@H](CC(C)C)C(=O)N[[email protected]@H](CCSC)C(=O)O)NC(=O)[[email protected]](C)NC(=O)CNC(=O)[[email protected]](CCCCN)NC(=O)[[email protected]](CC(=O)N)NC(=O)[[email protected]](CO)NC(=O)CN

StdInChI

InChI=1S/C45H81N13O14S/c1-9-24(5)36(43(69)50-21-35(63)52-29(17-23(3)4)40(66)55-28(45(71)72)14-16-73-8)58-44(70)37(25(6)10-2)57-38(64)26(7)51-34(62)20-49-39(65)27(13-11-12-15-46)54-41(67)30(18-32(48)60)56-42(68)31(22-59)53-33(61)19-47/h23-31,36-37,59H,9-22,46-47H2,1-8H3,(H2,48,60)(H,49,65)(H,50,69)(H,51,62)(H,52,63)(H,53,61)(H,54,67)(H,55,66)(H,56,68)(H,57,64)(H,58,70)(H,71,72)/t24-,25-,26-,27-,28-,29-,30-,31-,36-,37-/m0/s1

StdInChIKey

WIHBNMPFWRHGDF-SLVFWPMISA-N

Molecular Formula

C45H81N13O14S

Molecular Weight

1060.27

MDL Number

MFCD00133076

Properties

Appearance

White powder

Safety Data

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR 

NONH for all modes of transport

WGK Germany

3

Specifications and Other Information of Our Beta-Amyloid(25-35) CAS 131602-53-4

Identification Methods

HNMR, HPLC

Purity

98% min

Absorption coefficient

0 M-1cm-1

PI,isoelectric point

pH 10.12

Net charge at pH 7

1

Toxicity mechanism of Amyloid oligomer

  1. The effect on oxidative stress. Aβ can induce oxidative stress, produce a large number of free radicals, and then produce oxidative stress on neurons.
  2. Cause Ca2+ disorder. Aβ destroys the K+ channel on the cell membrane, causing a large amount of Ca2+ influx.
  3. Interaction with receptors on the cell membrane surface. Amyloid oligomers can activate excitatory NMDA2RS receptors, causing mitochondrial disorders and neuronal death.
  4. Amyloid in cells is also an important pathological feature. A large number of oligomers in the cells cause pathology. The production and degradation of Amyloid secreted by normal cells is relatively balanced.
  5. Break the balance between Bax and Bel-2.

Solubility evaluation

Poor water solubility

Shelf Life

2 years

Storage

Store at -20°C or -80°C for long time, Sealed and away from light

Known Application

Often used to study Alzheimer’s disease.

Apnoke Scientific Ltd

This product is developed by our sub R&D company Apnoke Scientific Ltd , and please click the link below for details. http://www.apnoke.com/beta-amyloid25-35-cas-131602-53-4/

Watson International Ltd

This product is sold exclusively through our sales company Watson International Ltd, and please click the link below for details. http://www.watson-int.com/beta-amyloid25-35-cas-131602-53-4/