Structure of Beta-Amyloid(1-40), CAS 131438-79-4

Beta-Amyloid(1-40), CAS 131438-79-4

Identification

CAS Number

131438-79-4

Name

Beta-Amyloid(1-40)

Peptide sequence

Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val

Synonyms

131438-79-4 [RN]
Abeta(1-40)
Abeta40
Amyloid β-Peptide (1-40) (human)
Human β-amyloid peptide (1-40)
β-amyloid 40
β-amyloid protein 40
??-Amyloid(1-40) Human
[131438-79-4]
144409-98-3 [RN]
amyloid ?? protein fragment 1-40
Amyloid ?-Peptide (1-40) (human)
amyloid-β polypeptide 40
Asp-ala-glu-phe-arg-his-asp-ser-gly-tyr-glu-val-his-his-gln-lys-leu-val-phe-phe-ala-glu-as p-val-gly-ser-asn-lys-gly-ala-ile-ile-gly-leu-met-val-gly-gly-val-val
Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val
DAEFGHDSGFEVRHQKLVFFAEDVGSNKGAIIGLMVGGVV
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:64646
L-α-aspartyl-L-alanyl-L-α-glutamyl-L-phenylalanyl-L-arginyl-L-histidyl-L-α-aspartyl-L-serylglycyl-L-tyrosyl-L-α-glutamyl-L-valyl-L-histidyl-L-histidyl-L-glutaminyl-L-lysyl-L-leucyl-L-valyl-L-phenylalanyl-L-phenylalanyl-L-alanyl-L-α-glutamyl-L-α-aspartyl-L-valylglycyl-L-seryl-L-asparaginyl-L-lysylglycyl-L-alanyl-L-isoleucyl-L-isoleucylglycyl-L-leucyl-L-methionyl-L-valylglycylglycyl-L-valyl-L-valine
MFCD00130509
MFCD00717583
Rat amyloid-β peptide 1-40
β-amyloid polypeptide 40
β-amyloid(1-40) human

SMILES

[H]/N=C(\N)/NCCC[[email protected]@H](C(=O)N[[email protected]@H](Cc1cnc[nH]1)C(=O)N[[email protected]@H](CC(=O)O)C(=O)N[[email protected]@H](CO)C(=O)NCC(=O)N[[email protected]@H](Cc2ccc(cc2)O)C(=O)N[[email protected]@H](CCC(=O)O)C(=O)N[[email protected]@H](C(C)C)C(=O)N[[email protected]@H](Cc3cnc[nH]3)C(=O)N[[email protected]@H](Cc4cnc[nH]4)C(=O)N[[email protected]@H](CCC(=O)N)C(=O)N[[email protected]@H](CCCCN)C(=O)N[[email protected]@H](CC(C)C)C(=O)N[[email protected]@H](C(C)C)C(=O)N[[email protected]@H](Cc5ccccc5)C(=O)N[[email protected]@H](Cc6ccccc6)C(=O)N[[email protected]@H](C)C(=O)N[[email protected]@H](CCC(=O)O)C(=O)N[[email protected]@H](CC(=O)O)C(=O)N[[email protected]@H](C(C)C)C(=O)NCC(=O)N[[email protected]@H](CO)C(=O)N[[email protected]@H](CC(=O)N)C(=O)N[[email protected]@H](CCCCN)C(=O)NCC(=O)N[[email protected]@H](C)C(=O)N[[email protected]@H]([[email protected]@H](C)CC)C(=O)N[[email protected]@H]([[email protected]@H](C)CC)C(=O)NCC(=O)N[[email protected]@H](CC(C)C)C(=O)N[[email protected]@H](CCSC)C(=O)N[[email protected]@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[[email protected]@H](C(C)C)C(=O)N[[email protected]@H](C(C)C)C(=O)O)NC(=O)[[email protected]](Cc7ccccc7)NC(=O)[[email protected]](CCC(=O)O)NC(=O)[[email protected]](C)NC(=O)[[email protected]](CC(=O)O)N

StdInChI

InChI=1S/C194H295N53O58S/c1-25-102(19)158(188(299)211-87-143(256)218-124(67-94(3)4)174(285)228-123(62-66-306-24)172(283)241-152(96(7)8)186(297)209-83-140(253)206-84-145(258)240-154(98(11)12)191(302)245-157(101(17)18)193(304)305)247-192(303)159(103(20)26-2)246-162(273)104(21)215-141(254)85-207-164(275)116(47-36-38-63-195)223-181(292)133(77-139(199)252)234-185(296)137(90-249)220-144(257)88-210-187(298)153(97(9)10)242-184(295)135(79-151(269)270)235-170(281)121(56-60-147(261)262)222-161(272)106(23)217-173(284)127(69-107-41-30-27-31-42-107)231-177(288)129(71-109-45-34-29-35-46-109)237-189(300)156(100(15)16)244-183(294)125(68-95(5)6)229-166(277)117(48-37-39-64-196)224-168(279)119(54-58-138(198)251)226-178(289)130(73-111-80-202-91-212-111)233-180(291)132(75-113-82-204-93-214-113)238-190(301)155(99(13)14)243-171(282)122(57-61-148(263)264)227-175(286)126(72-110-50-52-114(250)53-51-110)219-142(255)86-208-165(276)136(89-248)239-182(293)134(78-150(267)268)236-179(290)131(74-112-81-203-92-213-112)232-167(278)118(49-40-65-205-194(200)201)225-176(287)128(70-108-43-32-28-33-44-108)230-169(280)120(55-59-146(259)260)221-160(271)105(22)216-163(274)115(197)76-149(265)266/h27-35,41-46,50-53,80-82,91-106,115-137,152-159,248-250H,25-26,36-40,47-49,54-79,83-90,195-197H2,1-24H3,(H2,198,251)(H2,199,252)(H,202,212)(H,203,213)(H,204,214)(H,206,253)(H,207,275)(H,208,276)(H,209,297)(H,210,298)(H,211,299)(H,215,254)(H,216,274)(H,217,284)(H,218,256)(H,219,255)(H,220,257)(H,221,271)(H,222,272)(H,223,292)(H,224,279)(H,225,287)(H,226,289)(H,227,286)(H,228,285)(H,229,277)(H,230,280)(H,231,288)(H,232,278)(H,233,291)(H,234,296)(H,235,281)(H,236,290)(H,237,300)(H,238,301)(H,239,293)(H,240,258)(H,241,283)(H,242,295)(H,243,282)(H,244,294)(H,245,302)(H,246,273)(H,247,303)(H,259,260)(H,261,262)(H,263,264)(H,265,266)(H,267,268)(H,269,270)(H,304,305)(H4,200,201,205)/t102-,103-,104-,105-,106-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,152-,153-,154-,155-,156-,157-,158-,159-/m0/s1

StdInChIKey

FEWOUVRMGWFWIH-ILZZQXMPSA-N

Molecular Formula

C194H295N53O58S

Molecular Weight

4329.80

MDL Number

MFCD00130509

Properties

Appearance

White powder

Safety Data

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR 

NONH for all modes of transport

WGK Germany

3

Specifications and Other Information of Our Beta-Amyloid(1-40), CAS 131438-79-4

Identification Methods

HNMR, HPLC

Purity

98% min

Absorption coefficient

1280 M-1cm-1 

PI,isoelectric point

pH 5.17  

Net charge at pH 7

-2.7 

Solubility evaluation

Poor water solubility

Toxicity mechanism of Amyloid oligomer

  1. The effect on oxidative stress. Aβ can induce oxidative stress, produce a large number of free radicals, and then produce oxidative stress on neurons.
  2. Cause Ca2+ disorder. Aβ destroys the K+ channel on the cell membrane, causing a large amount of Ca2+ influx.
  3. Interaction with receptors on the cell membrane surface. Amyloid oligomers can activate excitatory NMDA2RS receptors, causing mitochondrial disorders and neuronal death.
  4. Amyloid in cells is also an important pathological feature. A large number of oligomers in the cells cause pathology. The production and degradation of Amyloid secreted by normal cells is relatively balanced.
  5. Break the balance between Bax and Bel-2.

Shelf Life

2 years

Storage

Store at -20°C or -80°C for long time, Sealed and away from light

Known Application

Often used to study Alzheimer’s disease.

Apnoke Scientific Ltd

This product is developed by our sub R&D company Apnoke Scientific Ltd , and please click the link below for details. http://www.apnoke.com/beta-amyloid1-40-cas-131438-79-4/

Watson International Ltd

This product is sold exclusively through our sales company Watson International Ltd, and please click the link below for details. http://www.watson-int.com/beta-amyloid1-40-cas-131438-79-4/