Structure of Ansamitocin P-3 CAS 66547-09-9

Ansamitocin P-3 CAS 66547-09-9

Identification

CAS Number

66547-09-9

Name

Ansamitocin P-3

Synonyms

(1S,2R,3R,5S,6S,16E,18E,20R,21S)-11-Chlor-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10(26),11,13,16,18-pentaen-6-yl-2-m ethylpropanoat [German] [ACD/IUPAC Name]
(1S,2R,3R,5S,6S,16E,18E,20R,21S)-11-Chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10(26),11,13,16,18-pentaen-6-yl 2- methylpropanoate [ACD/IUPAC Name]
2-Méthylpropanoate de (1S,2R,3R,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-diméthoxy-2,5,9,16-tétraméthyl-8,23-dioxo-4,24-dioxa-9,22-diazatétracyclo[19.3.1.110,14.03,5]hexacosa-10(26),11,13 ,16,18-pentaén-6-yle [French] [ACD/IUPAC Name]
66547-09-9 [RN]
66584-72-3 [RN]
Ansamitocin P3
MFCD00274586
OQ2293000
Propanoic acid, 2-methyl-, (1S,2R,3R,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,1 4(26),16,18-pentaen-6-yl ester [ACD/Index Name]
[66584-72-3]
Ansamitocin P-3
Maytansinoid AP-3

SMILES

C[[email protected]@H]1[[email protected]@H]2C[[email protected]]([[email protected]@H](/C=C/C=C(/Cc3cc(c(c(c3)OC)Cl)N(C(=O)C[[email protected]@H]([[email protected]]4([[email protected]@H]1O4)C)OC(=O)C(C)C)C)\C)OC)(NC(=O)O2)O

StdInChI

InChI=1S/C32H43ClN2O9/c1-17(2)29(37)43-25-15-26(36)35(6)21-13-20(14-22(40-7)27(21)33)12-18(3)10-9-11-24(41-8)32(39)16-23(42-30(38)34-32)19(4)28-31(25,5)44-28/h9-11,13-14,17,19,23-25,28,39H,12,15-16H2,1-8H3,(H,34,38)/b11-9+,18-10+/t19-,23+,24-,25+,28-,31+,32+/m1/s1

StdInChIKey

OPQNCARIZFLNLF-KUDLRRJMSA-N

Molecular Formula

C32H43ClN2O9 

Molecular Weight

635.14 

MDL Number

MFCD00274586

Properties

Appearance

White to almost white powder

Safety Data

Symbol

exclamation-mark-jpgGHS07

Signal Word

Warning

Hazard statements

H302 + H332 – H315 – H319 – H335

Precautionary Statements

P301 + P312 + P330 – P302 + P352 – P304 + P340 + P312 – P305 + P351 + P338

Target organs 

Respiratory system

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

RIDADR 

NONH for all modes of transport

WGK Germany

3

RTECS 

OQ2293000

Specifications and Other Information of Our Ansamitocin P-3 CAS 66547-09-9

Identification Methods

HNMR, HPLC

Purity

99% min

Storage

Under room temperature away from light

Known Application

Ansamitomicin P-3 is an ansamacrolide and maytansine analogue originally isolated from the Ethiopian shrub Maytenus serrata with antineoplastic activity. Ansamitomicin P-3 binds to tubulin at the maytansine-binding site, thereby inhibiting microtubule assembly, inducing microtubule disassembly, and disrupting mitosis.

General View of Documents

HNMR-1 of Ansamitocin P-3 CAS 66547-09-9
HNMR-1 of Ansamitocin P-3 CAS 66547-09-9
HNMR-2-of-Ansamitocin-P-3-CAS-66547-09-9
HNMR-2-of-Ansamitocin-P-3-CAS-66547-09-9
HNMR-3 of Ansamitocin P-3 CAS 66547-09-9
HNMR-3 of Ansamitocin P-3 CAS 66547-09-9
HNMR-4 of Ansamitocin P-3 CAS 66547-09-9
HNMR-4 of Ansamitocin P-3 CAS 66547-09-9
HNMR-5 of Ansamitocin P-3 CAS 66547-09-9
HNMR-5 of Ansamitocin P-3 CAS 66547-09-9
HNMR-6 of Ansamitocin P-3 CAS 66547-09-9
HNMR-6 of Ansamitocin P-3 CAS 66547-09-9
HPLC of Ansamitocin P-3 CAS 66547-09-9
HPLC of Ansamitocin P-3 CAS 66547-09-9

Watson Bio Ltd

This product is developed by our sub R&D company Watson Bio Ltd, and please click the link below for details. https://www.watson-bio.com/ansamitocin-p-3-cas-66547-09-9/

Watson International Ltd

This product is sold exclusively through our sales company Watson International Ltd, and please click the link below for details. http://www.watson-int.com/ansamitocin-p-3-cas-66547-09-9/