2-Cyanoethyl N,N,N’,N’-tetraisopropylphosphorodiamidite CAS 102691-36-1
Identification
Properties
Safety Data
Specifications & Other Information
Links
Identification
CAS Number
102691-36-1
Name
2-Cyanoethyl N,N,N’,N’-tetraisopropylphosphorodiamidite
Synonyms
102691-36-1 [RN]
2-Cyanethyl-N,N,N’,N’-tetraisopropylphosphorodiamidoit [German] [ACD/IUPAC Name]
2-Cyanoethyl N,N,N’,N’-tetraisopropyldiamidophosphite
2-Cyanoethyl N,N,N’,N’-tetraisopropylphosphorodiamidoite [ACD/IUPAC Name]
2-cyanoethyl N,N,N’,N’-tetrapropan-2-ylphosphorodiamidoite
2-Cyanoethyl-N,N,N’,N’-tetraisopropylphosphorodiamidite
2-Cyanoethyltetraisopropylphosphorodiamidite
N,N,N’,N’-Tétraisopropylphosphorodiamidoite de 2-cyanoéthyle [French] [ACD/IUPAC Name]
Phosphorodiamidous acid, N,N,N’,N’-tetrakis(1-methylethyl)-, 2-cyanoethyl ester [ACD/Index Name]
Phosphorodiamidous acid, tetrakis(1-methylethyl)-, 2-cyanoethyl ester
[102691-36-1]
¦Â-Cyanoethyl-N,N,N`,N`-tertraisopropylphosphorodiamidite
2-cyanoethyl N,N,N’,N’-tetraisopropyl-phosphordiamidite
2-Cyanoethyl N,N,N’,N’-tetra(prop-2-yl)phosphorodiamidoite
2-cyanoethyl N,N,N’,N’-tetraisopropyl-phosphordiamidite
2-Cyanoethyl N,N,N’,N’-Tetraisopropylphosphordiamidite
2-Cyanoethyl N,N,N’,N’-tetraisopropylphosphorodiamidite
2-Cyanoethyl N,N,N’,N’-tetrakis(isopropyl)phosphorodiamidite
2-Cyanoethyl N,N,N′,N′-tetraisopropylphosphordiamidite
2-Cyanoethyl tetraisopropylphosphorodiamidite
2-CyanoethylN,N,N’,N’-tetraisopropylphosphorodiamidite
3-((bis(diisopropylamino)phosphanyl)oxy)propanenitrile
3-((Bis(diisopropylamino)phosphino)oxy)propanenitrile
3-((Bis(diisopropylamino)phosphino)oxy)-propanenitrile
3-((Bis(diisopropylamino)phosphino)-oxy)propanenitrile
3-({bis[bis(propan-2-yl)amino]phosphanyl}oxy)propanenitrile
3-(bis(diisopropylamino)phosphinooxy)propanenitrile
3-{bis[bis(methylethyl)amino]phosphinooxy}propanenitrile
3-Bis(diisopropylamino)phosphanyloxypropanenitrile
3-bis[di(propan-2-yl)amino]phosphanyloxypropanenitrile
3-bis[di(propan-2-yl)amino]phosphinooxypropanenitrile
600-337-9 [EINECS]
Bis(diisopropylamino)(2-cyanoethoxy)phosphine
bis(N,N-diisopropylamino)-2-cyanoethoxyphosphine
Cetipd
MFCD00012213 [MDL number]
P-Reagent
SS-7739
Molecular Structure
SMILES
CC(C)N(C(C)C)P(N(C(C)C)C(C)C)OCCC#N
StdInChI
InChI=1S/C15H32N3OP/c1-12(2)17(13(3)4)20(19-11-9-10-16)18(14(5)6)15(7)8/h12-15H,9,11H2,1-8H3
StdInChIKey
RKVHNYJPIXOHRW-UHFFFAOYSA-N
Molecular Formula
C15H32N3OP
Molecular Weight
301.41
Beilstein Registry Number
3590103
MDL Number
MFCD00012213
Properties
Appearance
Colorless and Clear liquid
Refractive Index
n20/D 1.470(lit.)
Boiling Point
100 °C/0.5 mmHg(lit.)
Density
0.949 g/mL at 25 °C(lit.)
Flash Point
60°C
Safety Data
Symbol
Signal Word
Danger
Hazard Statements
Precautionary Statements
P261-P280-P305 + P351 + P338-P342 + P311
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
RIDADR
UN 1993C 3 / PGIII
WGK Germany
3
Specifications and Other Information of Our 2-Cyanoethyl N,N,N’,N’-tetraisopropylphosphorodiamidite CAS 102691-36-1
Standard
Enterprise standard
Identification Methods
H-NMR,P-NMR
Purity
99.5%min
Manufacturing Capacity
500kg-800kg/month
Storage
Store at low temperature (2-8°C) under nitrogen, sealed, dry, and protected from light.
Application
1. DNA/RNA Synthesis : Used to prepare nucleoside phosphoramidite monomers, serving as a crucial upstream reagent in solid-phase oligonucleotide synthesis.
2. Modified Oligonucleotides : Used in the synthesis of LNA, modified nucleosides, functionalized DNA/RNA, and antisense oligonucleotides.
3. Nucleic Acid Drugs : Serving the research and development and production of nucleic acid drugs such as siRNA and ASO.
4. Molecular Biology : Used in the synthesis of DNA primers, probes, and other custom oligonucleotides.
5. Phospholipid Synthesis : Can be used for the phosphorylation construction of some phospholipids/glycerophospholipids.
6. Carbohydrates and Glycopeptides : Can be used in the synthesis of phosphorus-containing sugars, glycopeptides, and other phosphorylated biomolecules.
7. Medicinal Chemistry : Used in the synthesis of phosphorus-containing nucleosides, nucleoside analogs, and other phosphorus-containing bioactive molecules.
Key Advantages
High value to the nucleic acid drug industry chain. Its downstream applications cover oligo synthesis, ASO, siRNA, gene detection, molecular diagnostics and nucleic acid drug research and development/production, thus having a relatively clear industrial application market.
Mature Application in Nucleic Acid Synthesis :
It is an important reagent in classic 2-cyanoethyl phosphoramidite chemistry, widely used in the synthesis of DNA/RNA oligonucleotides.
High Reactivity :
The P(III) center exhibits high reactivity, reacting efficiently with alcohol hydroxyl groups under the action of activators such as tetrazole and DCI to form phosphoramidite intermediates.
Suitable for Automated Solid-Phase Synthesis :
The formed nucleoside phosphoramidites can be used in automated oligonucleotide synthesizers, suitable for continuous, repetitive solid-phase synthesis processes.
Easy Removal of 2-Cyanoethyl Protecting Group :
β-Cyanoethyl is a classic phosphate protecting group, which can be easily removed during post-processing, facilitating the final acquisition of a stable phosphate/phosphodiester backbone.
Wide Applicability :
Not only suitable for ordinary DNA/RNA, but also for the synthesis of modified nucleosides, LNA, functionalized oligonucleotides, and other phosphorylated biomolecules.
General View of Documents
Links
Caming Pharmaceutical Ltd
This product is developed by our sub R&D company Caming Pharmaceutical Ltd, and please click the link below for details.
http://www.caming.com/2-cyanoethyl-nnnn-tetraisopropylphosphorodiamidite-cas-102691-36-1/
Watson International Ltd
This product is sold exclusively through our sales company Watson International Ltd, and please click the link below for details.
http://www.watson-int.com/2-cyanoethyl-nnnn-tetraisopropylphosphorodiamidite-cas-102691-36-1/